XPO4 - exportin 4 Gene

Homo sapiens

Also known as exp4

Gene ID: 64328 | Gene type: protein coding

About XPO4

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:20,777,329-20,902,774 (from NCBI)

This gene has 3 transcripts (splice variants), 219 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 3.0), heart (RPKM 2.8) and 25 other tissues.

Summary

XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and Other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]

XPO4 Products(2)

mRNA	Protein	Name
NM_001372061.1	NP_001358990.1	exportin-4 isoform 2
NM_022459.5	NP_071904.4	exportin-4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear export signal receptor activity	IDA IDA: Inferred from direct assay	10944119	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10944119	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	10944119	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of protein export from nucleus	IMP IMP: Inferred from mutant phenotype	16449645	GOA
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	10944119	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in nucleus	IDA IDA: Inferred from direct assay	10944119	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XPO4 Protein Structure

CRM1_C

0
200
400
600
800
1000
1151 a.a.

Protein Preferred Names

Protein Names

exportin-4

XPO4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83040	XPO4 Antibody (YA2785)	WB, IP	Human, Rat

Related Diseases

Diseases

Alias

Enamel Erosion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15890	XPO4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	XPO4	VGNC	VGNC:67112
Rattus norvegicus	XPO4	RGD	RGD:1312015
Canis familiaris	XPO4	VGNC	VGNC:48461
Bos taurus	XPO4	VGNC	VGNC:36998
Macaca mulatta	XPO4	VGNC	VGNC:79091
Mus musculus	XPO4	MGD	MGI:1888526

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