Htr6 - 5-hydroxytryptamine receptor 6 Gene

Rattus norvegicus

Gene ID: 64354 | Gene type: protein coding

About Htr6

Primary_assembly 5: 151,296,662-151,311,912 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 55 orthologues, 35 paralogues and is associated with 5 phenotypes. Restricted expression toward (RPKM 8.2).

Summary

Enables G protein-coupled serotonin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; long-term synaptic potentiation; and regulation of amine transport. Located in dendrite and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human HTR6 (5-hydroxytryptamine receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Htr6 Products(1)

mRNA	Protein	Name
NM_024365.2	NP_077341.2	5-hydroxytryptamine receptor 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	7680751	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	24614691	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IMP IMP: Inferred from mutant phenotype	7680751	RGD
involved in learning	IDA IDA: Inferred from direct assay	17192775	RGD
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	19660530	RGD
involved in negative regulation of acetylcholine secretion, neurotransmission	IMP IMP: Inferred from mutant phenotype	16987217	RGD
involved in negative regulation of gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	16987217	RGD
involved in negative regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	16987217	RGD
involved in positive regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	16987217	RGD
involved in positive regulation of gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	19660530	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17122082	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	10427606	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	10432491	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr6 Protein Structure

7tmA_5-HT6

0
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300
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438 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 6

5-HT-6	5-HT6
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	ST-B17
serotonin receptor 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06480	HTR6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06481	Htr6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06482	Htr6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr6	NCBI	NCBI:3362

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