GREM2 - gremlin 2, DAN family BMP antagonist Gene

Homo sapiens

Also known as PRDC; DAND3; STHAG9; CKTSF1B2

Gene ID: 64388 | Gene type: protein coding

About GREM2

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:240,489,573-240,612,155 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in gall bladder (RPKM 20.4), colon (RPKM 11.9) and 14 other tissues.

Summary

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]

GREM2 Products(1)

mRNA	Protein	Name
NM_022469.4	NP_071914.3	gremlin-2 precursor

GREM2 Protein Structure

DAN

0
100
168 a.a.

Protein Preferred Names

Protein Names

gremlin-2

DAN domain family member 3

Related Diseases

Diseases

Alias

Tooth Agenesis, Selective, 9

STHAG9

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Sclerosteosis

Cortical Hyperostosis With Syndactyly	Sost
Cortical Hyperostosis-Syndactyly Syndrome

Scleral Staphyloma

Scleral Ectasia

Staphyloma Of Sclera

Hereditary Mixed Polyposis Syndrome

Hmps

Anodontia

Complete Absence Of Teeth	Developmental Absence Of Tooth
Total Anodontia Of Permanent And Deciduous Teeth	Absence Of Permanent Teeth
Anodontia Of Permanent Dentition	Agomphiasis
Agomphosis	Anodontism
Complete Developmental Absence Of Teeth	Congenital Absence Of Teeth
Congenital Complete Absence Of Teeth	Congenital Edentia
Absence Of Teeth	Absent Teeth
Congenital Partial Absence Of Teeth	Partial Absence Of Teeth
Partial Anodontia

Syngnathia

Cleft Palate-Lateral Synechia Syndrome	Cpls Syndrome
Cleft Palate Lateral Synechia Syndrome

Synostoses, Tarsal, Carpal, And Digital

Calcaneonavicular Coalition	Multiple Synostosis Syndrome
Synostoses, Tarsal, Carpal And Digital

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05785	GREM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GREM2	VGNC	VGNC:41475
Rattus norvegicus	GREM2	RGD	RGD:1560008
Mus musculus	GREM2	MGD	MGI:1344367
Macaca mulatta	GREM2	VGNC	VGNC:106377
Felis catus	GREM2	VGNC	VGNC:107878
Others	GREM2	NCBI

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