GZF1 - GDNF inducible zinc finger protein 1 Gene

Homo sapiens

Also known as JLSM; ZBTB23; ZNF336

Gene ID: 64412 | Gene type: protein coding

About GZF1

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,361,127-23,373,062 (from NCBI)

This gene has 5 transcripts (splice variants), 192 orthologues, 51 paralogues and is associated with 3 phenotypes. Ubiquitous expression in adrenal (RPKM 10.9), bone marrow (RPKM 10.5) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GZF1 Products(3)

mRNA	Protein	Name
NM_001317012.2	NP_001303941.1	GDNF-inducible zinc finger protein 1 isoform a
NM_001317019.1	NP_001303948.1	GDNF-inducible zinc finger protein 1 isoform b
NM_022482.5	NP_071927.1	GDNF-inducible zinc finger protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16049025	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	16049025	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16049025	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	16049025	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16049025	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16049025	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16049025	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16049025	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GZF1 Protein Structure

BTB

zf-C2H2_6

zf-C2H2

zf-C2H2_4

zf-C2H2_6

zf-H2C2_2

0
200
400
600
711 a.a.

Protein Preferred Names

Protein Names

GDNF-inducible zinc finger protein 1

zinc finger and BTB domain-containing protein 23

Related Diseases

Diseases

Alias

Joint Laxity, Short Stature, And Myopia

JLSM	Severe Myopia-Generalized Joint Laxity-Short Stature Syndrome

Pectus Carinatum

Carinatum Deformity Of The Chest

Larsen Syndrome

LRS	Larsen Syndrome, Dominant Type
Dominant Larsen Syndrome	Autosomal Dominant Larsen Syndrome
Larsens Syndrome

Acute Salpingitis

Glycogen Storage Disease Ix

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05938	GZF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GZF1	VGNC	VGNC:62744
Rattus norvegicus	GZF1	RGD	RGD:1562321
Canis familiaris	GZF1	VGNC	VGNC:41576
Macaca mulatta	GZF1	VGNC	VGNC:73173
Bos taurus	GZF1	VGNC	VGNC:29732
Mus musculus	GZF1	MGD	MGI:1921783
Others	GZF1	NCBI

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