SH3BGRL - SH3 domain binding glutamate rich protein like Gene

Homo sapiens

Also known as SH3BGR; HEL-S-115

Gene ID: 6451 | Gene type: protein coding

About SH3BGRL

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:81,202,102-81,298,547 (from NCBI)

This gene has 4 transcripts (splice variants), 227 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 90.2), urinary bladder (RPKM 79.0) and 25 other tissues.

Summary

Predicted to enable SH3 domain binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

SH3BGRL Products(1)

mRNA	Protein	Name
NM_003022.3	NP_003013.1	adapter SH3BGRL

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein-RNA adaptor activity	IMP IMP: Inferred from mutant phenotype	34331014	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IMP IMP: Inferred from mutant phenotype	34331014	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cytoplasmic translational initiation	IMP IMP: Inferred from mutant phenotype	34331014	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	34331014	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	34870550	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3BGRL Protein Structure

SH3BGR

0
100
114 a.a.

Protein Preferred Names

Protein Names

adapter SH3BGRL

SH3 domain-binding glutamic acid-rich-like protein

SH3 domain binding glutamic acid-rich protein like

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12827	SH3BGRL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12828	SH3BGRL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12829	SH3BGRL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SH3BGRL	VGNC	VGNC:65099
Macaca mulatta	SH3BGRL	VGNC	VGNC:77200
Mus musculus	SH3BGRL	MGD	MGI:1930849
Rattus norvegicus	SH3BGRL	RGD	RGD:1560520
Canis familiaris	SH3BGRL	VGNC	VGNC:46116
Bos taurus	SH3BGRL	VGNC	VGNC:34564

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