2. Gene
  3. GPR135 - G protein-coupled receptor 135 Gene

GPR135 - G protein-coupled receptor 135 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HUMNPIIY20

Gene ID: 64582 | Gene type: protein coding

About GPR135

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:59,452,783-59,465,380 (from NCBI)

This gene has 2 transcripts (splice variants), 152 orthologues and 3 paralogues. Broad expression in testis (RPKM 3.7), ovary (RPKM 1.1) and 20 other tissues.

Summary

Enables Arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR135 Products(1)

mRNA Protein Name
NM_022571.6 NP_072093.2 G-protein coupled receptor 135
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables arrestin family protein binding IDA
IDA: Inferred from direct assay
28827538 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28827538 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endosome IDA
IDA: Inferred from direct assay
28827538 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
28827538 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR135 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (120 - 387)

  • 0
  • 100
  • 200
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  • 400
  • 494 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 135

probable G-protein coupled receptor 135

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05657 GPR135 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GPR135 VGNC VGNC:29549
Mus musculus GPR135 MGD MGI:2676315
Rattus norvegicus GPR135 RGD RGD:727844
Felis catus GPR135 VGNC VGNC:104395