SPANXC - SPANX family member C Gene

Homo sapiens

Also known as CTp11; CT11.3; SPANXE; SPANX-C; SPANX-E

Gene ID: 64663 | Gene type: protein coding

About SPANXC

Cytogenetic location: Xq27.2 Genomic coordinates (GRCh38): X:141,241,463-141,242,517 (from NCBI)

This gene has 1 transcript (splice variant), 3 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 12.8).

Summary

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of Cancer/testis antigens and represents a potential target for Cancer Immunotherapy. [provided by RefSeq, Jul 2008]

SPANXC Products(1)

mRNA	Protein	Name
NM_022661.4	NP_073152.2	sperm protein associated with the nucleus on the X chromosome C

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPANXC Protein Structure

SPAN-X

0
97 a.a.

Protein Preferred Names

Protein Names

sperm protein associated with the nucleus on the X chromosome C

Nuclear-associated protein SPAN-Xe

SPANXC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPANXC	Q9NY87	SETBP1	Homo sapiens	Q9Y6X0	Y2H Array	25416956
Intra	SPANXC	Q9NY87	SETBP1	Homo sapiens	Q9Y6X0	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13629	SPANXC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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