2. Gene
  3. MFSD1 - major facilitator superfamily domain containing 1 Gene

MFSD1 - major facilitator superfamily domain containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SMAP4; Minerva

Gene ID: 64747 | Gene type: protein coding

About MFSD1

Cytogenetic location: 3q25.32 Genomic coordinates (GRCh38): 3:158,802,054-158,829,716 (from NCBI)

This gene has 20 transcripts (splice variants), 232 orthologues and 6 paralogues. Ubiquitous expression in appendix (RPKM 32.7), esophagus (RPKM 31.9) and 25 other tissues.

Summary

Predicted to enable protein homodimerization activity. Predicted to be involved in protein localization to lysosome and protein stabilization. Predicted to be located in lysosome. [provided by Alliance of Genome Resources, Apr 2022]

MFSD1 Products(4)

mRNA Protein Name
NM_001167903.3 NP_001161375.2 major facilitator superfamily domain-containing protein 1 isoform 2
NM_001289406.3 NP_001276335.1 major facilitator superfamily domain-containing protein 1 isoform 3
NM_001289407.3 NP_001276336.1 major facilitator superfamily domain-containing protein 1 isoform 4
NM_022736.4 NP_073573.3 major facilitator superfamily domain-containing protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables dipeptide uniporter activity IDA
IDA: Inferred from direct assay
38507452 GOA
Biological Process GO Annotation Evidence Reference Source
involved in dipeptide transmembrane transport from lysosomal lumen to cytosol IDA
IDA: Inferred from direct assay
38507452 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
38507452 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MFSD1 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (50 - 403)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
Protein Preferred Names Protein Names

major facilitator superfamily domain-containing protein 1

smooth muscle cell-associated protein 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08387 MFSD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MFSD1 VGNC VGNC:31431
Rattus norvegicus MFSD1 RGD RGD:1305751
Felis catus MFSD1 VGNC VGNC:63474
Mus musculus MFSD1 MGD MGI:1914118
Canis familiaris MFSD1 VGNC VGNC:43195
Macaca mulatta MFSD1 VGNC VGNC:74584