ILRUN - inflammation and lipid regulator with UBA-like and NBR1-like domains Gene

Homo sapiens

Also known as FP852; C6orf106; dJ391O22.4

Gene ID: 64771 | Gene type: protein coding

About ILRUN

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,587,288-34,696,767 (from NCBI)

This gene has 3 transcripts (splice variants) and 262 orthologues. Ubiquitous expression in fat (RPKM 19.9), testis (RPKM 15.9) and 25 other tissues.

Summary

This gene encodes a protein with N-terminal ubiquitin-associated (UBA)-like and central neighbor of BRCA1 gene 1 (NBR1)-like domains. The protein acts an inhibitor of Antiviral and proinflammatory cytokine transcription and as a regulator of the renin-angiotensin-aldosterone system (RAAS). [provided by RefSeq, Jul 2021]

ILRUN Products(2)

mRNA	Protein	Name
NM_022758.6	NP_073595.2	protein ILRUN isoform b
NM_024294.4	NP_077270.1	protein ILRUN isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	29802199	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	29802199	GOA
involved in negative regulation of defense response to virus	IMP IMP: Inferred from mutant phenotype	29802199	GOA
involved in negative regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	29802199	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	29802199	GOA
involved in negative regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	29802199	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	29802199	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29802199	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ILRUN Protein Structure

UBA_4

0
100
200
298 a.a.

Protein Preferred Names

Protein Names

protein ILRUN

inflammation and lipid regulator with UBA-like and NBR1-like domains protein

Related Diseases

Diseases

Alias

Meninges Sarcoma

Meningeal Sarcoma	Sarcoma Of Meninges
Meningothelial Sarcoma	Leptomeningeal Sarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06789	ILRUN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ILRUN	RGD	RGD:1559829
Mus musculus	ILRUN	MGD	MGI:106281
Macaca mulatta	ILRUN	VGNC	VGNC:83428
Bos taurus	ILRUN	VGNC	VGNC:52675
Canis familiaris	ILRUN	VGNC	VGNC:49210
Felis catus	ILRUN	VGNC	VGNC:102443

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