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  2. P2RY12 - purinergic receptor P2Y12 Gene

P2RY12 - purinergic receptor P2Y12 Gene

Homo sapiens

Also known as HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)

Gene ID: 64805 | Gene type: protein coding

About P2RY12

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:151,336,843-151,384,753 (from NCBI)

This gene has 2 transcripts (splice variants), 182 orthologues, 6 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 25.8), fat (RPKM 4.8) and 4 other tissues.

Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

P2RY12 Products(2)

mRNA Protein Name
NM_022788.5 NP_073625.1 P2Y purinoceptor 12
NM_176876.3 NP_795345.1 P2Y purinoceptor 12
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled ADP receptor activity IDA
IDA: Inferred from direct assay
11104774 GOA
enables G protein-coupled ADP receptor activity IMP
IMP: Inferred from mutant phenotype
12578987 GOA
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11104774 GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12578987 GOA
involved in platelet aggregation IMP
IMP: Inferred from mutant phenotype
12578987 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
12578987 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RY12 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (49 - 298)

  • 0
  • 100
  • 200
  • 300
  • 342 a.a.
Protein Preferred Names Protein Names

P2Y purinoceptor 12

ADP-glucose receptor

G-protein coupled receptor SP1999

Gi-coupled ADP receptor HORK3

P2Y12 platelet ADP receptor

purinergic receptor P2RY12

purinergic receptor P2Y, G-protein coupled, 12

putative G-protein coupled receptor

Related Diseases

Diseases Alias
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Carotid Artery Disease

Carotid Artery Diseases

Disorder Of Carotid Artery

Intermediate Coronary Syndrome

Unstable Angina

Angina At Rest

Anginal Chest Pain At Rest

Impending Infarction

Preinfarction Angina

Worsening Angina

Angina, Unstable

Myocardial Preinfarction Syndrome

Angina Unstable

Crescendo Angina

Angina Decubitus

Acute Coronary Insufficiency

Unstable Angina Pectoris

Preinfarctional Angina Pectoris

Worsening Effort Angina

Preinfarction Syndrome

Unstable Angina Pectoris Syndrome

Unstable Anginal Attack

Unstable Cardiac Angina

Unstable Chest Angina

Unstable Heart Angina

De Novo Effort Angina Pectoris

Crescendo Angina Pectoris

Ua - [Unstable Angina]

Bleeding Disorder, Platelet-Type, 8

Bleeding Disorder Due To P2ry12 Defect

Platelet-Type Bleeding Disorder 8

BDPLT8

Adp Platelet Receptor P2y12 Defect

P2y12 Defect

Bleeding Disorder Due To Adp Platelet Receptor P2y12 Defect

Bleeding Disorder Due To P2y12 Defect

Bleeding Disorder Due To P2rx1 Defect, Somatic

Bleeding Disorder, Platelet-Type 8

Adp Platelet Receptor P2y12 Deficiency

P2ry12 Deficiency

P2y12 Deficiency

Bleeding Disorder, Platelet Type 8

Peripheral Artery Disease

Peripheral Arterial Disease

Peripheral Arterial Diseases

Bernard-Soulier Syndrome

Giant Platelet Syndrome

BSS

Von Willebrand Factor Receptor Deficiency

Bdplt1

Platelet Glycoprotein Ib Deficiency

Bernard-Soulier Syndrome, Type A1

Bernard-Soulier Syndrome, Type B

Bernard Soulier Syndrome

Deficiency Of Platelet Glycoprotein 1b

Hemorrhagiparous Thrombocytic Dystrophy

Bernard-Soulier Syndrome Type C

Bleeding Disorder, Platelet-Type, 1

Glycoprotein Ib, Platelet, Deficiency Of

Giant Platelet Disorder, Isolated

Giant Platelet Disease

Macrothrombocytopenia, Familial Bernard-Soulier Type

Bernard-Soulier Syndrome, Type C

Bernard - Soulier Thrombopathy

Hemorrhagic Dystrophic Thrombocytopenia

Thrombopathy, Bernard-Soulier

Platelet Glycoprotein 1b, Deficiency Of

Hemorrhagioparous Thrombocytic Dystrophy

Bernard-Soulier Syndrome Type A1

Bernard-Soulier Syndrome Type B

Bleeding Disorder Platelet-Type 1

Gpd

Macrothrombocytopenia, Familial, Bernard-Soulier Type

Mitral Valve Stenosis

Mitral Stenosis

Rheumatic Mitral Stenosis

Ms - [Mitral Stenosis]

Mitral Valvular Stricture

Mitral Valve Stricture

Mitral Stricture

Chronic Mitral Stenosis

Mitral Obstruction

Mitral Valve Obstruction

Mitral Stenosis With Incompetence

Mitral Stenosis With Regurgitation

Rheumatic Mitral Insufficiency With Obstruction

Persistent Mild Asthma
Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Disease, Susceptibility To

Coronary Artery Anomaly

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident

Transient Cerebral Ischemia

Transient Ischemic Attack

Transient Ischemic Attacks

Tia

Tia - Transient Ischaemic Attack

Transient Cerebral Ischaemia

Ischemic Attack, Transient

Intermittent Cerebral Ischemia

Tia - [Transient Ischaemic Attack]

Intermittent Cerebral Ischaemia

Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified

Carotid Artery Thrombosis
Glanzmann Thrombasthenia 1

Glanzmann Thrombasthenia

Thrombasthenia Of Glanzmann And Naegeli

Bdplt2

Platelet Glycoprotein Iib-Iiia Deficiency

Glanzmann'S Thrombasthenia

Deficiency Of Platelet Fibrinogen Receptor

GT1

Gt

Platelet Fibrinogen Receptor Deficiency

Glycoprotein Complex Iib-Iiia Deficiency

Deficiency Of Glycoprotein Complex Iib-Iiia

Glycoprotein Iib/Iiia Defect

Glanzmann Thrombasthenia, Type A

Thrombasthenia

Bleeding Disorder, Platelet-Type, 2

Gp Iib-Iiia Complex Deficiency

Deficiency Of Gp Iib-Iiia Complex

Platelet-Type Bleeding Disorder 2

Thrombocytasthenia

Deficiency Of Gp 2b 3a Complex

Diacyclothrombopathia 2b 3a

Glanzmann Thrombasthenia Type A

Platelet Fibrinogen Receptor, Deficiency Of

Platelet Glycoprotein 2b 3a Deficiency

Glanzmann Disease

Glanzmann-Naegeli Disorder

Hereditary Hemorrhagic Thrombasthenia

Hereditary Thrombasthenia

Bleeding Disorder Platelet-Type 2

Thrombosis

Thrombosis Of Blood Vessel

Active Peptic Ulcer Disease

Gi Bleeding

Active Peptic Ulcer

Gastrointestinal Hemorrhage

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Coronary Thrombosis

Coronary Artery Thrombosis

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect

Cerebrovascular Disease

Cerebrovascular Accident

Cerebrovascular Disorder

Cerebrovascular Disorders

Cva

Stroke

Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Nizon-Isidor Syndrome

NIZIDS

Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Spinal Cord Vascular Diseases

Vascular Tissue Disease

Vascular Anomaly

Angina Pectoris

Prinzmetal'S Variant Angina

Prinzmetal Angina

Variant Angina

Angina

Angina Inversa

Prinzmetal'S Angina

Coronary Artery Vasospasm

Angina Pectoris, Variant

Variant Angina Pectoris

Vasospastic Angina

Angor Pectoris

Anginal Syndrome

Ischaemic Chest Pain

Angina Pectoris Syndrome

Angina Syndrome

Cardiac Angina Syndrome

Ap - [Angina Pectoris]

Angina Nos

Ap - [Angina Pectoris] Syndrome

Ischaemic Heart Disease With Angina

Heart Angina

Chest Angina

Angina Attack

Anginal Cardiopathy

Coronary Pain Nos

Aspirin Allergy

Acetylsalicylic Acid Allergy

Asa Allergy

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Cardiovascular Disease

Heart Conduction Disease

Conduction Disorder Of The Heart

Heart Rhythm Disease

Hemorrhagic Disease

Hemorrhagic Disorders

Hemorrhagic Diathesis

Hemorrhagic Diseases

Bleeding Tendency

Acquired Coagulation Factor Inhibitor Disorder

Acquired Inhibitor Of Coagulation

Antithrombinaemia

Antithromboplastinogenaemia

Circulating Anticoagulant Disorder

Haemorrhagic Disorder Due To Antithrombinaemia

Haemorrhagic Disorder Due To Excess Administered Heparin

Antithromboplastinaemia

Haemorrhagic Disorder Due To Hyperheparinemia

Cerebral Arterial Disease

Cerebral Arterial Diseases

Bleeding Disorder, Platelet-Type, 11

BDPLT11

Glycoprotein Vi Deficiency

Gp Vi Deficiency

Platelet-Type Bleeding Disorder 11

Bleeding Diathesis Due To A Collagen Receptor Defect

Bleeding Diathesis Due To Glycoprotein Vi Deficiency

Platelet-Type Bleeding Disorder-11

Bleeding Disorder, Platelet Type 11

Hemorrhage

Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1

Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia

Hereditary Diffuse Leukoencephalopathy With Spheroids

Alsp

Gpsc

Subcortical Gliosis Of Neumann

Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids

Hdls

HDLS1

Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia

Gliosis, Familial Progressive Subcortical

Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1

Leukoencephalopathy, Diffuse Hereditary, With Spheroids

Pold

Pigmentary Orthochromatic Leukodystrophy

Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia

Familial Progressive Subcortical Gliosis

Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant

Dementia, Familial, Neumann Type

Adult-Onset Leukodystrophy With Neuroaxonal Spheroids

Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids

Neuroaxonal Leukodystrophy

Fpsg

Familial Dementia, Neumann Type

Familial Dementia Neumann Type

Leukoencephalopathy, Diffuse Hereditary, With Spheroid

Intracranial Thrombosis

Cerebral Thrombosis

Thrombosis Of Cerebral Veins

Cerebral Arterial Thrombosis

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Diabetes Mellitus

Diabetes

Gastroduodenal Crohn'S Disease

Upper Gi Crohn'S Disease

Left Bundle Branch Hemiblock

Left Bundle Branch Block

Left Bundle-Branch Block

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus P2RY12 MGD MGI:1918089
Canis familiaris P2RY12 VGNC VGNC:44214
Macaca mulatta P2RY12 VGNC VGNC:75642
Rattus norvegicus P2RY12 RGD RGD:621681
Bos taurus P2RY12 VGNC VGNC:32525
Felis catus P2RY12 VGNC VGNC:64010