CDCP1 - CUB domain containing protein 1 Gene

Homo sapiens

Also known as CD318; TRASK; SIMA135

Gene ID: 64866 | Gene type: protein coding

About CDCP1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,082,277-45,146,482 (from NCBI)

This gene has 3 transcripts (splice variants) and 269 orthologues. Broad expression in esophagus (RPKM 12.2), skin (RPKM 11.1) and 15 other tissues.

Summary

This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

CDCP1 Products(2)

mRNA	Protein	Name
NM_022842.5	NP_073753.3	CUB domain-containing protein 1 isoform 1 precursor
NM_178181.3	NP_835488.1	CUB domain-containing protein 1 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21233420	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CUB domain-containing protein 1

membrane glycoprotein gp140

CDCP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDCP1	Q9H5V8	YES1	Homo sapiens	P07947	Anti Bait CoIP	21233420
Intra	CDCP1	Q9H5V8	SRC	Homo sapiens	P12931	Anti Bait CoIP	21725358
Intra	CDCP1	Q9H5V8	SRC	Homo sapiens	P12931	Anti Bait CoIP	21233420
Intra	CDCP1	Q9H5V8	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	CDCP1	Q9H5V8	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	CDCP1	Q9H5V8	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	CDCP1	Q9H5V8	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	CDCP1	Q9H5V8	SDCBP	Homo sapiens	O00560	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDCP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70109	CDCP1 Protein, Human (312a.a, HEK293, His)	Q9H5V8-3 (F30-S341)	≥95%
HY-P77891	CDCP1 Protein, Human (HEK293, His)	Q9H5V8-1 (F30-L666)	≥95%
HY-P77892	CDCP1 Protein, Human (HEK293, Fc)	Q9H5V8-1 (F30-L666)	≥95%
HY-P77893	CDCP1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9H5V8-1 (F30-L666)	≥95%
HY-P700969	CDCP1 Protein, Human (339a.a, HEK293, His)	Q9H5V8-1 (F30-R368)	≥95%

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02318	CDCP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDCP1	VGNC	VGNC:39018
Macaca mulatta	CDCP1	VGNC	VGNC:70849
Rattus norvegicus	CDCP1	RGD	RGD:1305578
Felis catus	CDCP1	VGNC	VGNC:60671
Bos taurus	CDCP1	VGNC	VGNC:27089
Mus musculus	CDCP1	MGD	MGI:2442010
Macaca fascicularis	CDCP1	NCBI	NCBI:102129146
Others	CDCP1	NCBI

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