LPIN3 - lipin 3 Gene

Homo sapiens

Also known as SMP2; LIPN3L; dJ620E11.2

Gene ID: 64900 | Gene type: protein coding

About LPIN3

Cytogenetic location: 20q12 Genomic coordinates (GRCh38): 20:41,340,821-41,360,582 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 3 paralogues. Ubiquitous expression in duodenum (RPKM 19.3), skin (RPKM 16.1) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate Phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and Phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

LPIN3 Products(2)

mRNA	Protein	Name
NM_001301860.2	NP_001288789.1	phosphatidate phosphatase LPIN3 isoform 1
NM_022896.3	NP_075047.1	phosphatidate phosphatase LPIN3 isoform 2

LPIN3 Protein Structure

Lipin_N

LNS2

0
200
400
600
800
851 a.a.

Protein Preferred Names

Protein Names

phosphatidate phosphatase LPIN3

Related Diseases

Diseases

Alias

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Peroneal Neuropathy

Peroneal Neuropathies

Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence	Fads
Fetal Akinesia Sequence	FADS1
Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia	Pena-Shokeir Syndrome Type 1
Fetal Akinesia Deformation Sequence Syndrome	Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome
Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia	Pena-Shokeir Syndrome, Type I
Foetal Akinesia Deformation Sequence Syndrome	Foetal Akinesia Sequence
Fetal Akinesia Deformation Sequence Syndrome 1	Pena-Shokeir Syndrome, Type 1
Pena Shokeir Syndrome, Type 1	Akinesia, Fetal, Deformation Sequence
Akinesia, Fetal, Deformation Sequence, Type 1	Pena-Shokeir Syndrome Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07771	LPIN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LPIN3	MGD	MGI:1891342
Rattus norvegicus	LPIN3	RGD	RGD:1588534
Bos taurus	LPIN3	VGNC	VGNC:30968
Macaca mulatta	LPIN3	VGNC	VGNC:74289
Felis catus	LPIN3	VGNC	VGNC:63270
Canis familiaris	LPIN3	VGNC	VGNC:42753

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