MRPS5 - mitochondrial ribosomal protein S5 Gene

Homo sapiens

Also known as S5mt; MRP-S5

Gene ID: 64969 | Gene type: protein coding

About MRPS5

Cytogenetic location: 2q11.1 Genomic coordinates (GRCh38): 2:95,085,369-95,122,003 (from NCBI)

This gene has 15 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 9.5), duodenum (RPKM 9.0) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]

MRPS5 Products(4)

mRNA	Protein	Name
NM_001321995.2	NP_001308924.1	28S ribosomal protein S5, mitochondrial isoform b
NM_001321996.2	NP_001308925.1	28S ribosomal protein S5, mitochondrial isoform c
NM_001321997.2	NP_001308926.1	28S ribosomal protein S5, mitochondrial isoform c
NM_031902.5	NP_114108.1	28S ribosomal protein S5, mitochondrial isoform a

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
part of mitochondrial small ribosomal subunit	IDA IDA: Inferred from direct assay	25838379	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPS5 Protein Structure

Ribosomal_S5

Ribosomal_S5_C

0
100
200
300
400
430 a.a.

Protein Preferred Names

Protein Names

28S ribosomal protein S5, mitochondrial

mitochondrial 28S ribosomal protein S5

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 15

Hypertrophic Cardiomyopathy 15	CMH15
Cardiomyopathy, Hypertrophic, 15	Cardiomyopathy Familial Hypertrophic 15
Cardiomyopathy, Familial Hypertrophic 15	Cardiomyopathy, Hypertrophic, Familial, Type 15

Borderline Leprosy

Midborderline Leprosy	Borderline Or Dimorphous Leprosy
Leprosy, Borderline

Hypotonia-Cystinuria Syndrome

Cystinuria With Mitochondrial Disease	2p21 Microdeletion Syndrome
HCS	Homozygous 2p16 Deletion Syndrome, Formerly
2p21 Deletion Syndrome	Del(2)(P21)
Monosomy 2p21	Atypical Hypotonia-Cystinuria Syndrome
Atypical Hcs

Raynaud-Claes Syndrome

Mrx49	MRXSRC
Mental Retardation, X-Linked 49	Mrx15
Clcn4-Related X-Linked Intellectual Disability Syndrome	Mental Retardation, X-Linked 15
X-Linked Mental Retardation 15	X-Linked Mental Retardation 49
Mental Retardation, X-Linked-49

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08688	MRPS5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MRPS5	VGNC	VGNC:63626
Rattus norvegicus	MRPS5	RGD	RGD:1308318
Bos taurus	MRPS5	VGNC	VGNC:31675
Mus musculus	MRPS5	MGD	MGI:1924971
Canis familiaris	MRPS5	VGNC	VGNC:43425

Name
Email *

	Sorry, but the email address you supplied was invalid.