MARCKSL1 - MARCKS like 1 Gene

Homo sapiens

Also known as F52; MLP; MRP; MLP1; MACMARCKS

Gene ID: 65108 | Gene type: protein coding

About MARCKSL1

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:32,333,839-32,336,233 (from NCBI)

This gene has 1 transcript (splice variant), 124 orthologues and 1 paralogue. Broad expression in ovary (RPKM 132.8), brain (RPKM 127.5) and 24 other tissues.

Summary

This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and Calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]

MARCKSL1 Products(1)

mRNA	Protein	Name
NM_023009.7	NP_075385.1	MARCKS-related protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24863880	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MARCKSL1 Protein Structure

MARCKS

0
100
195 a.a.

Protein Preferred Names

Protein Names

MARCKS-related protein

MARCKS-like protein 1

Related Diseases

Diseases

Alias

Valproate Embryopathy

Fetal Valproate Syndrome	Fetal Valproic Acid Syndrome
Fvs	Valproic Acid Embryopathy
Fetal Valproate Spectrum Disorder	Valproate Embryopathy, Susceptibility To
Foetal Valproate Syndrome	Foetal Valproic Acid Syndrome
Susceptibility To Valproate Embryopathy	Valproic Acid Antenatal Infection

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08146	MARCKSL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MARCKSL1	VGNC	VGNC:31245
Canis familiaris	MARCKSL1	VGNC	VGNC:43022
Rattus norvegicus	MARCKSL1	RGD	RGD:621197
Macaca mulatta	MARCKSL1	VGNC	VGNC:74723
Felis catus	MARCKSL1	VGNC	VGNC:107582
Mus musculus	MARCKSL1	MGD	MGI:97143

Name
Email *

	Sorry, but the email address you supplied was invalid.