WNK2 - WNK lysine deficient protein kinase 2 Gene

Homo sapiens

Also known as PRKWNK2; NY-CO-43; SDCCAG43; P/OKcl.13

Gene ID: 65268 | Gene type: protein coding

About WNK2

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:93,184,139-93,320,569 (from NCBI)

This gene has 15 transcripts (splice variants), 333 orthologues, 6 paralogues and is associated with 88 phenotypes. Broad expression in heart (RPKM 6.5), colon (RPKM 6.3) and 18 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

WNK2 Products(2)

mRNA	Protein	Name
NM_001282394.3	NP_001269323.1	serine/threonine-protein kinase WNK2 isoform 1
NM_006648.4	NP_006639.3	serine/threonine-protein kinase WNK2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	35044719	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in monoatomic ion homeostasis	IMP IMP: Inferred from mutant phenotype	21733846	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	17667937	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17667937	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	23797875	GOA
involved in positive regulation of sodium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21733846	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	17667937	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	21733846	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17667937	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNK2 Protein Structure

Pkinase

OSR1_C

0
400
800
1200
1600
2000
2297 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase WNK2

antigen NY-CO-43

Related Diseases

Diseases

Alias

Hypomagnesemia 4, Renal

Renal Hypomagnesemia 4	HOMG4
Hypomagnesemia, Renal, Normocalciuric	Hypomagnesemia 4
Renal Hypomagnesemia Normocalciuric	Hypomagnesemia, Type 4, Renal

Suprasellar Meningioma

Angiomatous Meningioma

Pseudohypoaldosteronism

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100626	WNK463	Inhibitor	99.75%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WNK2	RGD	RGD:1307284
Canis familiaris	WNK2	VGNC	VGNC:54853
Mus musculus	WNK2	MGD	MGI:1922857
Macaca mulatta	WNK2	VGNC	VGNC:78961
Bos taurus	WNK2	VGNC	VGNC:36950

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