SLC8A3 - solute carrier family 8 member A3 Gene

Homo sapiens

Also known as NCX3

Gene ID: 6547 | Gene type: protein coding

About SLC8A3

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:70,044,215-70,189,405 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 7 paralogues. Biased expression in brain (RPKM 2.0), adrenal (RPKM 0.3) and 4 other tissues.

Summary

This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]

SLC8A3 Products(6)

mRNA	Protein	Name
NM_001130417.3	NP_001123889.1	sodium/calcium exchanger 3 isoform G
NM_033262.5	NP_150287.1	sodium/calcium exchanger 3 isoform A precursor
NM_058240.4	NP_489479.1	sodium/calcium exchanger 3 isoform B precursor
NM_182932.3	NP_891977.1	sodium/calcium exchanger 3 isoform D precursor
NM_182936.3	NP_891981.1	sodium/calcium exchanger 3 isoform F
NM_183002.3	NP_892114.1	sodium/calcium exchanger 3 isoform C precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21959935	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21959935	GOA
located in synapse	IDA IDA: Inferred from direct assay	21382638	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC8A3 Protein Structure

Na_Ca_ex

Calx-beta

Na_Ca_ex

0
200
400
600
800
927 a.a.

Protein Preferred Names

Protein Names

sodium/calcium exchanger 3

Na(+)/Ca(2+)-exchange protein 3

Related Diseases

Diseases

Alias

Schnyder Corneal Dystrophy

Schnyder Crystalline Corneal Dystrophy	SCCD
Corneal Dystrophy, Crystalline, Of Schnyder	Corneal Dystrophy, Schnyder Type
Corneal Dystrophy Crystalline Of Schnyder	Crystalline Stromal Dystrophy
Hereditary Crystalline Stromal Dystrophy Of Schnyder	Scd
Corneal Dystrophy, Schnyder	Schnyder Crystalline Dystrophy Sine Crystals
Dystrophy, Corneal, Crystalline, Schnyder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13339	SLC8A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC8A3	VGNC	VGNC:46482
Mus musculus	SLC8A3	MGD	MGI:107976
Felis catus	SLC8A3	VGNC	VGNC:65430
Bos taurus	SLC8A3	VGNC	VGNC:34937
Macaca mulatta	SLC8A3	VGNC	VGNC:77636
Rattus norvegicus	SLC8A3	RGD	RGD:620197

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