SLC9A3 - solute carrier family 9 member A3 Gene

Homo sapiens

Also known as NHE3; DIAR8; NHE-3

Gene ID: 6550 | Gene type: protein coding

About SLC9A3

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:470,456-524,449 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 238 orthologues, 10 paralogues and is associated with 3 phenotypes. Biased expression in colon (RPKM 56.4), kidney (RPKM 51.3) and 9 other tissues.

Summary

The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]

SLC9A3 Products(2)

mRNA	Protein	Name
NM_001284351.3	NP_001271280.1	sodium/hydrogen exchanger 3 isoform 2
NM_004174.4	NP_004165.2	sodium/hydrogen exchanger 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	35613257	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	35613257	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16159897	GOA
enables sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	26358773	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of intracellular pH	IDA IDA: Inferred from direct assay	35613257	GOA
involved in sodium ion import across plasma membrane	IDA IDA: Inferred from direct assay	26358773	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	25851603	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	16501490	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26358773	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	35613257	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC9A3 Protein Structure

Na_H_Exchanger

0
200
400
600
834 a.a.

Protein Preferred Names

Protein Names

sodium/hydrogen exchanger 3

Na(+)/H(+) exchanger 3

Related Diseases

Diseases

Alias

Diarrhea 8, Secretory Sodium, Congenital

Congenital Secretory Sodium Diarrhea 8	DIAR8
Diarrhea, Congenital Sodium	Csd
Congenital Secretory Diarrhea, Sodium Type

Diarrhea 3, Secretory Sodium, Congenital, With Or Without Other Congenital Anomalies

Diarrhea 3, Secretory Sodium, Congenital, Syndromic	Congenital Secretory Sodium Diarrhea 3
Congenital Sodium Diarrhea	DIAR3
Csd	Sodium Diarrhea, Congenital
Congenital Secretory Sodium Diarrhea 3 Syndromic	Congenital Secretory Sodium Diarrhea 3 With Or Without Other Congenital Anomalies
Congenital Secretory Sodium Diarrhoea 3	Congenital Secretory Sodium Diarrhoea 3 Syndromic
Congenital Secretory Sodium Diarrhoea 3 With Or Without Other Congenital Anomalies	Na-H Exchange Deficiency
Non-Syndromic Congenital Sodium Diarrhea	Diarrhea, Type 3, Secretory Sodium, Congenital, Syndromic
Congenital Secretory Diarrhea, Sodium Type

Secretory Diarrhea

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Metabolic Acidosis

Hypertrophy Of Tongue Papillae

Tongue Papillary Hypertrophy

Hypertrophy Of Foliate Papillae

Inflammatory Diarrhea

Ileus

Ileus Of Intestine

Diarrhea 1, Secretory Chloride, Congenital

DIAR1	Chloride Diarrhea, Congenital, Finnish Type
Congenital Secretory Chloride Diarrhea 1	Congenital Chloride Diarrhea Finnish Type
Congenital Chloride Diarrhea	Chloridorrhea, Congenital
Congenital Chloride Diarrhoea Finnish Type	Congenital Chloridorrhea
Congenital Secretory Chloride Diarrhoea 1	Chloridorrhea Congenital
Cld	Diarrhea 1 Secretory Chloride Congenital
Diarrhea, Type 1, Chloride, Secretory, Congenital

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Ureteral Obstruction

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens	CBAVD
Cavd	Congenital Bilateral Aplasia Of Vas Deferens
Congenital Bilateral Absence Of The Vas Deferens	Congenital Bilateral Agenesis Of Vas Deferens
Absence Of Vas Deferens	Absent Vasa
Congenital Absence Of Vas Deferens	Congenital Aplasia Of Vas Deferens
Absent Vas Deferens	Vas Deferens, Congenital Bilateral Absence

Short Bowel Syndrome

Short Gut Syndrome	Acquired Short Bowel Syndrome
Secondary Short Bowel Syndrome	Short Bowel Nos

Leptospirosis

Fort Bragg Fever	Weil Disease
Leptospirosis Icterohaemorrhagica	Nanukayami Fever
Canicola Fever	Hemorrhagic Jaundice
Mud Fever	Stuttgart Disease
Swamp Fever	Rat Catcher'S Yellows
Spirochetal Jaundice	Weil'S Disease
Cane-Cutter Fever	Icterohemorrhagic Fever
Rice-Field Fever	Swineherd'S Disease
Weil Syndrome	Nanukayami
Canine Leptospirosis	Equine Infectious Anemia
Leptospirosis Canicola	Fever Due To Leptospira Autumnalis
Gikiyami	Leptospira Interrogans Autumnalis Infection
Leptospira Interrogans Canicola Infection	Leptospira Interrogans Hebdomadis Infection
Leptospira Interrogans Pomona Infection	Nanukayami Disease
Pretibial Fever	Seven-Day Fever
Eia - [Equine Infectious Anaemia]	Leptospira Interrogans Infection

Spermatocele

Osmotic Diarrhea

Microvillus Inclusion Disease

Congenital Microvillous Atrophy	Intractable Diarrhea Of Infancy
Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities	Davidson Disease
Microvillous Inclusion Disease	Congenital Microvillus Atrophy
Mvid	Diarrhea 2 With Microvillus Atrophy
Mvd	Congenital Familial Protracted Diarrhea
Davidson'S Disease	Familial Enteropathy, Microvillus
Microvillus Atrophy, Congenital	Congenital Enteropathy
Familial Protracted Enteropathy	Microvillous Atrophy
Microvillus Atrophy With Diarrhea 2	Idi

Congenital Diarrhea

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Corneal Dystrophy, Band-Shaped

Band Keratopathy

Band-Shaped Keratopathy

Diarrhea 5, With Tufting Enteropathy, Congenital

Congenital Diarrhea 5 With Tufting Enteropathy	Congenital Tufting Enteropathy
DIAR5	Cte
Intestinal Epithelial Cell Dysplasia	Tufting Enteropathy
Ied	Intestinal Epithelial Dysplasia
Enteropathy, Congenital Tufting	Congenital Diarrhoea 5 With Tufting Enteropathy
Congenital Familial Intractable Diarrhea With Epithelial Or Epithelium Abnormalities	Congenital Familial Intractable Diarrhoea With Epithelial Or Epithelium Abnormalities
Congenital Enteropathy	Congenital Familial Intractable Diarrhea With Enterocytes Assembly Abnormalities
Non-Syndromic Congenital Tufting Enteropathy	Diarrhea, Type 5, With Tufting Enteropathy, Congenital
Intestinal Intraepithelial Neoplasia

Acute Diarrhea

Hypokalemia

Potassium Deficiency	Potassium Deficiency Disorder
Hypopotassemia	Potassium
Potassium [K] Deficiency	Hypokalaemic Syndrome
Hypopotassaemia	Hypopotassaemia Syndrome
Hypokalaemic	Potassium Depletion

Dent Disease 1

Dent Disease	Dent'S Disease
Dent Disease 2	Dent Disease Type 1
DENT1	Urolithiasis, Hypercalciuric, X-Linked
Nephrolithiasis 2	Nphl2
Dent Syndrome	Dents Disease
Low-Molecular-Weight Proteinuria With Hypercalciuria And Nephrocalcinosis	Renal Fanconi Syndrome With Nephrocalcinosis And Renal Stones
X-Linked Recessive Hypercalciuric Hypophosphatemic Rickets	X-Linked Recessive Nephrolithiasis
Fanconi Syndrome, Renal, With Nephrocalcinosis And Renal Stones	Nephrolithiasis, Hypercalciuric, X-Linked
Nephrolithiasis-Hypercalciuria X-Linked Recessive	Nephrolithiasis, X-Linked Recessive
Dent Disease, Type 1

Intestinal Impaction

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Acute Kidney Failure

Acute Renal Failure	Acute Kidney Injury
Renal Failure Acute	Kidney Failure, Acute
Pre-Renal Acute Kidney Injury	Nontraumatic Acute Kidney Injury
Aki - [Acute Kidney Injury]	Arf - [Acute Kidney Failure]
Acute Kidney Disease	Acute Kidney Impairment
Acute Ischaemic Renal Failure	Acute Hypoxic Kidney Failure
Acute Kidney Shutdown	Acute Renal Oedema
Acute Renal Impairment	Acute Kidney Collapse
Acute Necrotising Kidney	Acute Renal Suppression

Renal Tubular Acidosis

Acidosis Renal Tubular	Acidosis, Renal Tubular
Lightwood-Albright Syndrome	Lightwood Syndrome
Idiopathic Infantile Hypercalcemia - Mild Form	Kidney Tubular Acidosis
Renal Tubule Acidosis	Kidney Acidosis
Renal Acidosis	Renal Hyperchloremic Acidosis
Rta - [Renal Tubular Acidosis]

Corneal Degeneration

Degenerative Corneal Opacity

Renal Tubular Transport Disease

Renal Tubular Transport, Inborn Errors

Inborn Renal Tubular Transport Disorder

Dysentery

Infectious Diarrhea

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Liddle Syndrome 1

Liddle Syndrome	Pseudoaldosteronism
Liddle'S Syndrome	LIDLS1
Lidls	Pseudohyperaldosteronism
Pseudoprimary Hyperaldosteronism	Pseudohyperaldosteronism Type 1
Liddles Syndrome

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

Diabetes Mellitus

Diabetes

Polyhydramnios

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13343	SLC9A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC9A3	MGD	MGI:105064
Felis catus	SLC9A3	VGNC	VGNC:65433
Rattus norvegicus	SLC9A3	RGD	RGD:3720
Bos taurus	SLC9A3	VGNC	VGNC:34940
Canis familiaris	SLC9A3	VGNC	VGNC:53464
Macaca mulatta	SLC9A3	VGNC	VGNC:77638
Others	SLC9A3	NCBI