SLC11A1 - solute carrier family 11 member 1 Gene

Homo sapiens

Also known as LSH; NRAMP; NRAMP1

Gene ID: 6556 | Gene type: protein coding

About SLC11A1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,382,273-218,396,894 (from NCBI)

This gene has 18 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in lung (RPKM 10.4), appendix (RPKM 8.8) and 7 other tissues.

Summary

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

SLC11A1 Products(1)

mRNA	Protein	Name
NM_000578.4	NP_000569.3	natural resistance-associated macrophage protein 1

SLC11A1 Protein Structure

Nramp

0
100
200
300
400
500
550 a.a.

Protein Preferred Names

Protein Names

natural resistance-associated macrophage protein 1

Leishmaniasis resistance

Related Diseases

Diseases

Alias

Buruli Ulcer

Buruli Ulcer, Susceptibility To	Buruli Ulcer Disease
Mycobacterium Ulcerans	Mycobacterium Ulcerans, Susceptibility To
Bairnsdale Ulcer	Daintree Ulcer
Mossman Ulcer	Searl Ulcer
Searle'S Ulcer	Bud

Typhoid Fever

Typhoid	Enteric Fever
Typhoidal Salmonellosis	Ileotyphus
Infection By Salmonella Typhi	Typhoid Any Site
Typhoid Fever Any Site	Typhoid Infection
Typhoid Infection Any Site	Typhoid Fever Confirmed
Enteric Fever Nos

Leishmaniasis

Post-Kala-Azar Dermal Leishmaniasis	Post Kala-Azar Dermal Leishmaniasis
Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis	Cutaneous Leishmaniasis
Kala-Azar	Visceral Leishmaniasis
Leishmaniasis, Cutaneous	Leishmaniasis, Visceral
Leishmania	Leishmania Infection
Leishmaniosis

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Pulmonary Tuberculosis

Tuberculosis, Pulmonary	PTB
Tuberculosis Pulmonary

Tularemia

Francisella Tularensis Infection	Deerfly Fever
Lemming Fever	Ohara Disease
Pahvant Valley Plague	Rabbit Fever
Yatobyo

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Visceral Leishmaniasis

Kala-Azar	Leishmaniasis, Visceral
Infection By Visceral Leishmaniasis	Leishmaniasis Visceral
Sahib Disease	Ponos
Burdwan Fever	Mard El Bicha
Sirkari Disease	Indian Visceral Leishmaniasis
Dumdum Fever	Visceral Leishmaniasis Due To Leishmania Donovani

Brucellosis

Mediterranean Fever	Malta Fever
Undulant Fever	Gibraltar Fever
Bang'S Disease	Maltese Fever
Cyprus Fever	Rock Fever
Brucellosis Infection	Brucella Infection

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Q Fever

Infection Due To Coxiella Burnetii	Quadrilateral Fever
Query Fever	Nine Mile Fever
Coxiella Burnetii Fever	Q Fever Pneumonia
Coxiellosis	Pneumonia In Q Fever
Australian Q Fever	Balkan Grippe

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis	Juvenile Chronic Polyarthritis
Monarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Arthritis
Still'S Disease	Systemic Juvenile Rheumatoid Arthritis
Juvenile Chronic Arthritis	Acute Juvenile Rheumatoid Arthritis
Pauciarticular Onset Juvenile Chronic Arthritis	Arthritis, Juvenile Rheumatoid
Jia	Jra
Juvenile Ra	Arthritis Juvenile Rheumatoid
Stills Disease	Juvenile Arthritis
Acute Polyarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis, Systemic Juvenile

Septicemic Plague

Plague, Septicemic

Lymphadenitis

Acute Lymphadenitis	Chronic Lymphadenitis
Adenitis	Chronic Adenitis
Acute Adenitis	Inflammation Of Lymph Node
Adenitis Nos	Inflammation Of Gland
Lymphatic Gland Inflammation	Lymph Gland Inflammation
Polyadenitis	Chronic Adenitis Of Any Lymph Node Except Mesenteric
Chronic Lymphadenitis Except Mesenteric	Chronic Non-Specific Lymphadenitis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Type 1 Diabetes Mellitus 7

Diabetes Mellitus, Insulin-Dependent, 7	Iddm7
Insulin-Dependent Diabetes Mellitus 7	T1D7

Salmonellosis

Salmonella Infections

Salmonella Infection

Macs Syndrome

Macrocephaly, Alopecia, Cutis Laxa, And Scoliosis	Mycobacterium Avium Complex Disease
Rin2 Syndrome	Mycobacterium Avium-Intracellulare Infection
Tall Forehead, Sparse Hair, Skin Hyperextensibility, And Scoliosis	Mycobacterium Avium Complex
Mycobacterium Avium Infection	Infection Due To Mycobacterium Intracellulare
Mac Disease	Macrocephaly-Alopecia-Cutis Laxa-Scoliosis Syndrome
Rin2 Deficiency	Tall Forehead-Sparse Hair-Skin Hyperextensibility-Scoliosis Syndrome
MACS	Macrocephaly Alopecia Cutis Laxa And Scoliosis Syndrome

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Iron Metabolism Disease

Iron Deficiency	Iron Disorder
Iron Metabolism Disorders	Disorder Of Iron Metabolism
Iron	Fe Deficiency
Iron Storage Disease	Iron Storage Disorder

Type 1 Diabetes Mellitus 17

Diabetes Mellitus, Insulin-Dependent, 17	Iddm17
Insulin-Dependent Diabetes Mellitus 17	TID17
Insulin-Dependent Diabetes Mellitus-17

Gastrointestinal Tularemia

Enteric Tularemia

Intestinal Tularaemia

Primary Bacterial Infectious Disease

Laryngeal Tuberculosis

Tuberculosis, Laryngeal

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Sarcoidosis 1

Sarcoidosis	Boeck Sarcoid
Besnier-Boeck-Schaumann Disease	SS1
Sarcoidosis, Susceptibility To, 1	Lymphogranulomatosis
Hodgkin Disease	Boeck'S Disease
Boeck'S Sarcoid	Schaumann'S Disease Or Syndrome
Hutchinson-Boeck Disease Or Syndrome

Urogenital Tuberculosis

Tuberculosis, Urogenital

Genitourinary Tuberculosis

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Borderline Leprosy

Midborderline Leprosy	Borderline Or Dimorphous Leprosy
Leprosy, Borderline

Tuberculoid Leprosy

Smooth Leprosy	Type T Leprosy
Leprosy Tuberculoid	Leprosy, Tuberculoid

Indeterminate Leprosy

Uncharacteristic Leprosy

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Lepromatous Leprosy

Leprosy, Lepromatous	Type L Leprosy
Leprosy Lepromatous

Splenic Disease

Splenic Diseases	Dyssplenism
Spleen Disease	Abnormality Of The Spleen
Spleen Diseases

Microcytic Anemia

Iron-Refractory Iron Deficiency Anemia

Extrapulmonary Tuberculosis

EPTB	Tuberculosis, Extrapulmonary

Mucocutaneous Leishmaniasis

American Cutaneous Leishmaniasis	American Mucocutaneous Leishmaniasis
Cutaneous Leishmaniasis, American	Mucocutaneous Leishmaniasis, American
New World Cutaneous Leishmaniasis	Leishmaniasis, Mucocutaneous
Espundia	Leishmania Braziliensis Infection

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12994	SLC11A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC11A1	RGD	RGD:1601463
Bos taurus	SLC11A1	VGNC	VGNC:34663
Felis catus	SLC11A1	VGNC	VGNC:65186
Macaca mulatta	SLC11A1	VGNC	VGNC:77382
Canis familiaris	SLC11A1	VGNC	VGNC:46216
Mus musculus	SLC11A1	MGD	MGI:1345275
Others	SLC11A1	NCBI