2. Gene
  3. SLCO1A2 - solute carrier organic anion transporter family member 1A2 Gene

SLCO1A2 - solute carrier organic anion transporter family member 1A2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OATP; OATP-A; OATP1A2; SLC21A3

Gene ID: 6579 | Gene type: protein coding

About SLCO1A2

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:21,264,600-21,419,634 (from NCBI)

This gene has 17 transcripts (splice variants), 159 orthologues and 10 paralogues. Biased expression in brain (RPKM 6.2), lung (RPKM 0.9) and 2 other tissues.

Summary

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]

SLCO1A2 Products(37)

mRNA Protein Name
NM_001386878.1 NP_001373807.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386879.1 NP_001373808.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386880.1 NP_001373809.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386881.1 NP_001373810.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386882.2 NP_001373811.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386886.1 NP_001373815.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386887.1 NP_001373816.1 solute carrier organic anion transporter family member 1A2 isoform 4
NM_001386890.1 NP_001373819.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386908.1 NP_001373837.1 solute carrier organic anion transporter family member 1A2 isoform 8
NM_001386919.1 NP_001373848.1 solute carrier organic anion transporter family member 1A2 isoform 8
NM_001386920.1 NP_001373849.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386921.1 NP_001373850.1 solute carrier organic anion transporter family member 1A2 isoform 10 precursor
NM_001386922.1 NP_001373851.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386926.1 NP_001373855.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386927.1 NP_001373856.1 solute carrier organic anion transporter family member 1A2 isoform 8
NM_001386929.1 NP_001373858.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386931.1 NP_001373860.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386937.1 NP_001373866.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386938.1 NP_001373867.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386939.1 NP_001373868.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386940.1 NP_001373869.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386946.1 NP_001373875.1 solute carrier organic anion transporter family member 1A2 isoform 7 precursor
NM_001386947.1 NP_001373876.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386948.1 NP_001373877.1 solute carrier organic anion transporter family member 1A2 isoform 3 precursor
NM_001386949.1 NP_001373878.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386951.1 NP_001373880.1 solute carrier organic anion transporter family member 1A2 isoform 6 precursor
NM_001386952.1 NP_001373881.1 solute carrier organic anion transporter family member 1A2 isoform 3 precursor
NM_001386953.1 NP_001373882.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386954.1 NP_001373883.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386958.1 NP_001373887.1 solute carrier organic anion transporter family member 1A2 isoform 5 precursor
NM_001386959.1 NP_001373888.1 solute carrier organic anion transporter family member 1A2 isoform 9 precursor
NM_001386960.1 NP_001373889.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386961.1 NP_001373890.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386962.1 NP_001373891.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386963.1 NP_001373892.1 solute carrier organic anion transporter family member 1A2 isoform 12
NM_021094.4 NP_066580.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_134431.5 NP_602307.1 solute carrier organic anion transporter family member 1A2 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables organic anion transmembrane transporter activity IDA
IDA: Inferred from direct assay
10873595 GOA
enables transmembrane transporter activity IDA
IDA: Inferred from direct assay
25132355 GOA
Cellular Component GO Annotation Evidence Reference Source
located in basal plasma membrane IDA
IDA: Inferred from direct assay
35307651 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
25132355 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLCO1A2 Protein Structure

OATP

OATP: Organic Anion Transporter Polypeptide (OATP) family (20 - 598)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (445 - 486)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
Protein Preferred Names Protein Names

solute carrier organic anion transporter family member 1A2

OATP-1

Related Diseases

Diseases Alias
Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome
Carbapenem Allergy
Intrahepatic Cholestasis

Cholestasis, Intrahepatic

Neonatal Intrahepatic Cholestasis

Cholestasis Intrahepatic

Cholestasis Of Pregnancy
Cholelithiasis
Allan-Herndon-Dudley Syndrome

AHDS

Allan-Herndon Syndrome

Monocarboxylate Transporter 8 Deficiency

MCT8 DEFICIENCY

Mental Retardation, X-Linked, With Hypotonia

Triiodothyronine Resistance

T3 Resistance

Mental Retardation And Muscular Atrophy

Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency

Intellectual Disability And Muscular Atrophy

Monocarboxylate Transporter-8 Deficiency

T3 Resisitence

Triiodothyronine Resistence

X-Linked Intellectual Disability With Hypotonia

Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency

Monocarboxylate Transporter 8 Deficiency

X-Linked Intellectual Disability-Hypotonia Syndrome
Dubin-Johnson Syndrome

DJS

Chronic Idiopathic Jaundice

Jaundice, Chronic Idiopathic

Hyperbilirubinemia, Dubin-Johnson Type

Hyperbilirubinemia Ii

Hyperbilirubinemia Type 2

Conjugated Hyperbilirubinemia

Dubin-Sprinz Disease

Sprinz-Nelson Syndrome

Hblrdj

Dubin Johnson Syndrome

Hyperbilirubinemia 2

Black Liver-Jaundice Syndrome

Chronic Idiopathic Jaundice With Pigmented Liver

Dubin-Sprinz Syndrome

Hyperbilirubinaemia Type 2

Djs - [Dubin-Johnson Syndrome]
Cholestasis, Benign Recurrent Intrahepatic, 1

Benign Recurrent Intrahepatic Cholestasis

BRIC1

Summerskill Syndrome

Bric

Summerskill-Walshe-Tygstrup Syndrome

Cholestasis, Benign Recurrent Intrahepatic

Benign Recurrent Intrahepatic Cholestasis 1

Benign Recurrent Intrahepatic Cholestasis Type 1

Bric Type 1

Low Gamma-Gt Familial Intrahepatic Cholestasis

Recurrent Familial Intrahepatic Cholestasis

Cholestasis, Benign Recurrent Intrahepatic 1

Mild Atp8b1 Deficiency

Recurrent Familial Intrahepatic Cholestasis 1

Abcb11-Related Intrahepatic Cholestasis

Atp8b1-Related Intrahepatic Cholestasis

Cholestasis, Intrahepatic, Recurrent, Benign, Type 1

Progressive Intrahepatic Cholestasis

Cholestasis, Progressive Familial Intrahepatic 3

Bric - [Benign Recurrent Intrahepatic Cholestasis]
Extrahepatic Cholestasis

Cholestasis, Extrahepatic

Extrahepatic Biliary Stasis

Extrahepatic Obstructive Biliary Disease

Cholestasis Extrahepatic
Intrahepatic Cholestasis Of Pregnancy

Recurrent Intrahepatic Cholestasis Of Pregnancy

Gravidic Intrahepatic Cholestasis

Pregnancy-Related Cholestasis

Icp

Pregnancy Related Cholestasis

Cholestasis, Intrahepatic Of Pregnancy

Familial Intrahepatic Cholestasis Of Pregnancy

Familial Recurrent Intrahepatic Cholestasis Of Pregnancy

Ricp

Obstetric Cholestasis
Bilirubin Metabolic Disorder

Hyperbilirubinemia

Hereditary Hyperbilirubinemia

Hyperbilirubinemia, Hereditary

Hyperbilirubinaemia
Gilbert Syndrome

Gilbert Disease

Gilbert'S Disease

Gilbert'S Syndrome

Cholemia, Familial

Familial Nonhemolytic Jaundice

Meulengracht Syndrome

Gilbert Syndrome, Susceptibility To

Hyperbilirubinemia, Gilbert Type

Hblrg

Hyperbilirubinemia, Arias Type

Hyperbilirubinemia I

Constitutional Hyperbilirubinemia

Gilbert-Meulengracht Syndrome

Hereditary Nonhemolytic Jaundice

Hyperbilirubinemia Arias Type

Hyperbilirubinemia Type 1

Constitutional Liver Dysfunction

Gilbert-Lereboullet Syndrome

Hyperbilirubinemia 1

Unconjugated Benign Bilirubinemia

GILBS

Gilberts Syndrome

Familial Nonhaemolytic Jaundice

Constitutional Hyperbilirubinaemia

Hereditary Nonhaemolytic Bilirubinaemia

Familial Nonhaemolytic Bilirubinaemia

Idiopathic Hyperbilirubinaemia

Icterus Intermittens Juvenilis

Chronic Intermittent Juvenile Jaundice

Low-Grade Chronic Hyperbilirubinaemia Syndrome

Benign Unconjugated Bilirubinaemia Syndrome

Hereditary Nonhaemolytic Jaundice

Idiopathic Unconjugated Hyperbilirubinaemia

Gilbert--Lereboullet Syndrome

Constitutional Hepatic Dysfunction

Meulengracht Icterus

Cholaemia Familiaris Simplex

Familial Cholaemia

Congenital Familial Cholaemia

Physiologic Cholaemia

Hyperbilirubinaemia Type 1

Gilbert Cholaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13351 SLCO1A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLCO1A2 VGNC VGNC:65442
Macaca mulatta SLCO1A2 VGNC VGNC:77601
Canis familiaris SLCO1A2 VGNC VGNC:46493
Bos taurus SLCO1A2 VGNC VGNC:34949
Rattus norvegicus SLCO1A2 RGD RGD:621389
Others SLCO1A2 NCBI