2. Gene
  3. SLC22A3 - solute carrier family 22 member 3 Gene

SLC22A3 - solute carrier family 22 member 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EMT; EMTH; OCT3

Gene ID: 6581 | Gene type: protein coding

About SLC22A3

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:160,348,378-160,452,577 (from NCBI)

This gene has 1 transcript (splice variant), 527 orthologues and 22 paralogues. Biased expression in liver (RPKM 29.4), prostate (RPKM 6.3) and 10 other tissues.

Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and Other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

SLC22A3 Products(1)

mRNA Protein Name
NM_021977.4 NP_068812.1 solute carrier family 22 member 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables monoamine transmembrane transporter activity IDA
IDA: Inferred from direct assay
10196521 GOA
enables monoamine transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
23505051 GOA
enables neurotransmitter transmembrane transporter activity IDA
IDA: Inferred from direct assay
10196521 GOA
enables neurotransmitter transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
23505051 GOA
enables organic cation transmembrane transporter activity EXP
EXP: Inferred from Experiment
19141712 GOA
enables organic cation transmembrane transporter activity IDA
IDA: Inferred from direct assay
10966924 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
enables quaternary ammonium group transmembrane transporter activity IDA
IDA: Inferred from direct assay
10966924 GOA
enables toxin transmembrane transporter activity IDA
IDA: Inferred from direct assay
22806583 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular detoxification IDA
IDA: Inferred from direct assay
22806583 GOA
involved in dopamine transport IDA
IDA: Inferred from direct assay
16581093 GOA
involved in dopamine uptake IDA
IDA: Inferred from direct assay
20858707 GOA
involved in epinephrine transport IDA
IDA: Inferred from direct assay
10196521 GOA
involved in epinephrine uptake IDA
IDA: Inferred from direct assay
20858707 GOA
involved in histamine transport IDA
IDA: Inferred from direct assay
16581093 GOA
involved in histamine uptake IDA
IDA: Inferred from direct assay
20858707 GOA
involved in histamine uptake IMP
IMP: Inferred from mutant phenotype
23505051 GOA
involved in monoamine transport IMP
IMP: Inferred from mutant phenotype
23505051 GOA
involved in neurotransmitter transport IDA
IDA: Inferred from direct assay
20858707 GOA
involved in norepinephrine transport IDA
IDA: Inferred from direct assay
10196521 GOA
involved in norepinephrine uptake IDA
IDA: Inferred from direct assay
20858707 GOA
acts upstream of or within organic cation transport IDA
IDA: Inferred from direct assay
10966924 GOA
involved in organic cation transport IDA
IDA: Inferred from direct assay
22806583 GOA
acts upstream of or within quaternary ammonium group transport IDA
IDA: Inferred from direct assay
10966924 GOA
involved in quaternary ammonium group transport IDA
IDA: Inferred from direct assay
20858707 GOA
involved in serotonin transport IDA
IDA: Inferred from direct assay
10196521 GOA
involved in serotonin uptake IDA
IDA: Inferred from direct assay
20858707 GOA
involved in xenobiotic transport IDA
IDA: Inferred from direct assay
20858707 GOA
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15817714 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15817714 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
20858707 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A3 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (159 - 485)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 556 a.a.
Protein Preferred Names Protein Names

solute carrier family 22 member 3

EMT organic cation transporter 3

Related Diseases

Diseases Alias
Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8

Iddm8

Insulin-Dependent Diabetes Mellitus 8

T1D8

Insulin-Dependent Diabetes Mellitus-8
Extragonadal Seminoma

Primary Extragonadal Seminoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13074 SLC22A3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC22A3 VGNC VGNC:34727
Mus musculus SLC22A3 MGD MGI:1333817
Macaca mulatta SLC22A3 VGNC VGNC:77418
Canis familiaris SLC22A3 VGNC VGNC:46278
Felis catus SLC22A3 VGNC VGNC:65245
Rattus norvegicus SLC22A3 RGD RGD:3701