SLC22A2 - solute carrier family 22 member 2 Gene

Homo sapiens

Also known as OCT2

Gene ID: 6582 | Gene type: protein coding

About SLC22A2

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:160,216,755-160,258,821 (from NCBI)

This gene has 6 transcripts (splice variants), 327 orthologues and 22 paralogues. Restricted expression toward kidney (RPKM 70.1).

Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and Other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]

SLC22A2 Products(1)

mRNA	Protein	Name
NM_003058.4	NP_003049.2	solute carrier family 22 member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-amino acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23864433	GOA
enables L-arginine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23864433	GOA
enables acetylcholine transmembrane transporter activity	IDA IDA: Inferred from direct assay	15817714	GOA
enables amine transmembrane transporter activity	IDA IDA: Inferred from direct assay	9687576	GOA
enables choline transmembrane transporter activity	IDA IDA: Inferred from direct assay	9687576	GOA
enables efflux transmembrane transporter activity	IDA IDA: Inferred from direct assay	9687576	GOA
enables monoamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	9687576	GOA
enables neurotransmitter transmembrane transporter activity	IDA IDA: Inferred from direct assay	9687576	GOA
enables organic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	11907186	GOA
enables organic cation transmembrane transporter activity	EXP EXP: Inferred from Experiment	19141712	GOA
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	9260930	GOA
enables organic cation transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23864433	GOA
enables prostaglandin transmembrane transporter activity	IDA IDA: Inferred from direct assay	11907186	GOA
enables putrescine transmembrane transporter activity	IDA IDA: Inferred from direct assay	21128598	GOA
enables pyrimidine nucleoside transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	GOA
enables quaternary ammonium group transmembrane transporter activity	IDA IDA: Inferred from direct assay	9260930	GOA
enables thiamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	24961373	GOA
enables toxin transmembrane transporter activity	IDA IDA: Inferred from direct assay	9687576	GOA
enables toxin transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	12395288	GOA
enables xenobiotic transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-alpha-amino acid transmembrane transport	IMP IMP: Inferred from mutant phenotype	23864433	GOA
involved in L-arginine import across plasma membrane	IMP IMP: Inferred from mutant phenotype	23864433	GOA
involved in acetylcholine transport	IDA IDA: Inferred from direct assay	15817714	GOA
involved in amine transport	IDA IDA: Inferred from direct assay	9687576	GOA
involved in amino acid import across plasma membrane	IMP IMP: Inferred from mutant phenotype	23864433	GOA
involved in cellular detoxification	IDA IDA: Inferred from direct assay	9687576	GOA
involved in cellular detoxification	IMP IMP: Inferred from mutant phenotype	20477935	GOA
involved in choline transport	IDA IDA: Inferred from direct assay	9687576	GOA
involved in dopamine transport	IDA IDA: Inferred from direct assay	16581093	GOA
involved in dopamine uptake	IDA IDA: Inferred from direct assay	9687576	GOA
involved in epinephrine transport	IDA IDA: Inferred from direct assay	16581093	GOA
involved in export across plasma membrane	IDA IDA: Inferred from direct assay	9687576	GOA
involved in histamine transport	IDA IDA: Inferred from direct assay	16581093	GOA
involved in histamine uptake	IDA IDA: Inferred from direct assay	9687576	GOA
involved in neurotransmitter transport	IDA IDA: Inferred from direct assay	9687576	GOA
involved in norepinephrine transport	IDA IDA: Inferred from direct assay	9687576	GOA
involved in norepinephrine uptake	IDA IDA: Inferred from direct assay	9687576	GOA
acts upstream of or within organic cation transport	IDA IDA: Inferred from direct assay	16024787	GOA
involved in organic cation transport	IDA IDA: Inferred from direct assay	9687576	GOA
involved in organic cation transport	IMP IMP: Inferred from mutant phenotype	23864433	GOA
involved in prostaglandin transport	IDA IDA: Inferred from direct assay	11907186	GOA
involved in putrescine transport	IDA IDA: Inferred from direct assay	21128598	GOA
involved in serotonin transport	IDA IDA: Inferred from direct assay	9687576	GOA
involved in serotonin uptake	IDA IDA: Inferred from direct assay	9687576	GOA
involved in thiamine transmembrane transport	IDA IDA: Inferred from direct assay	24961373	GOA
involved in xenobiotic transport	IDA IDA: Inferred from direct assay	9687576	GOA
involved in xenobiotic transport	IMP IMP: Inferred from mutant phenotype	20477935	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15817714	GOA
located in basal plasma membrane	IDA IDA: Inferred from direct assay	35307651	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23137377	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A2 Protein Structure

Sugar_tr

0
100
200
300
400
500
555 a.a.

Protein Preferred Names

Protein Names

solute carrier family 22 member 2

organic cation transporter 2

Related Diseases

Diseases

Alias

Carnitine Deficiency, Systemic Primary

Carnitine Uptake Defect	Renal Carnitine Transport Defect
Systemic Primary Carnitine Deficiency	CDSP
Systemic Carnitine Deficiency	Carnitine Transporter Deficiency
Cud	Primary Carnitine Deficiency
Carnitine Uptake Deficiency	Carnitine Deficiency, Systemic, Due To Defect In Renal Reabsorption Of Carnitine
Carnitine Deficiency, Primary	Systemic Primary Carnitine Deficiency Disease
Deficiency Of Plasma-Membrane Carnitine Transporter	Scd
Carnitine Transporter, Plasma-Membrane, Deficiency Of	Carnitine Transport Defect
Carnitine Plasma-Membrane Transporter Deficiency	Carnitine Transporter Defect
Spcd

Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8	Iddm8
Insulin-Dependent Diabetes Mellitus 8	T1D8
Insulin-Dependent Diabetes Mellitus-8

Cataract 37

CTRCT37	Cca5
Cataract, Congenital, Cerulean Type, 5	Cataract 37, Autosomal Dominant
Congenital Cataract Cerulean Type 5

Cholestasis

Obstruction Of Bile Duct	Bile Duct Obstruction
Bile Occlusion	Extrahepatic Biliary Obstruction
Extrahepatic Bile Duct Obstruction	Bile Stasis
Biliary Stasis	Obstructive Hyperbilirubinemia
Obstructed Jaundice	Bile Duct Obstructed
Bile Ductal Obstruction	Biliary Duct Obstruction
Obstructed Bile Ductal	Obstructed Biliary Duct
Obstructed Biliary Ductal	Jaundice Regurgitation
Obstructive Jaundice	Cholestatic Jaundice
Cholestatic Jaundice Syndrome

Fanconi-Like Syndrome

Fanconi Like Syndrome

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Cystoisosporiasis

Isosporiasis	Infection By Isospora Belli And Isospora Hominis
Isosporosis	Infection By Isospora Belli Or Isospora Hominis
Isospora Belli Or Hominis Infection	Coccidial Infestation
Coccidiosis	Coccidial Dysentery
Intestinal Coccidiosis Nos

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13072	SLC22A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC22A2	MGD	MGI:1335072
Felis catus	SLC22A2	VGNC	VGNC:99773
Rattus norvegicus	SLC22A2	RGD	RGD:61936
Bos taurus	SLC22A2	VGNC	VGNC:53805
Canis familiaris	SLC22A2	VGNC	VGNC:53985
Macaca mulatta	SLC22A2	VGNC	VGNC:83465
Others	SLC22A2	NCBI

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