SLIT3 - slit guidance ligand 3 Gene

Homo sapiens

Also known as MEGF5; SLIL2; SLIT1; slit2; Slit-3

Gene ID: 6586 | Gene type: protein coding

About SLIT3

Cytogenetic location: 5q34-q35.1 Genomic coordinates (GRCh38): 5:168,661,740-169,301,139 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and 25 paralogues. Broad expression in fat (RPKM 23.0), gall bladder (RPKM 21.4) and 22 other tissues.

Summary

The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

SLIT3 Products(2)

mRNA	Protein	Name
NM_001271946.2	NP_001258875.2	slit homolog 3 protein isoform 1 precursor
NM_003062.4	NP_003053.2	slit homolog 3 protein isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Roundabout binding	IPI IPI: Inferred from physical interaction	15207848	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Roundabout signaling pathway	IMP IMP: Inferred from mutant phenotype	18829537	GOA
involved in apoptotic process involved in luteolysis	IEP IEP: Inferred from expression pattern	18566128	GOA
involved in axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	16840550	GOA
involved in axon guidance	IDA IDA: Inferred from direct assay	11748139	GOA
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	18566128	GOA
NOT involved in chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration	IDA IDA: Inferred from direct assay	11748139	GOA
involved in negative chemotaxis	IDA IDA: Inferred from direct assay	11748139	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18829537	GOA
involved in negative regulation of chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18829537	GOA
involved in response to cortisol	IEP IEP: Inferred from expression pattern	18566128	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	19741192	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLIT3 Protein Structure

LRRNT

LRR_8

LRRCT

LRRNT

LRR_8

LRRCT

LRRNT

LRR_8

LRRCT

LRRNT

LRR_8

LRRCT

EGF

Laminin_G_2

hEGF

EGF

hEGF

0
300
600
900
1200
1523 a.a.

Protein Preferred Names

Protein Names

slit homolog 3 protein

multiple EGF-like domains protein 5

Related Diseases

Diseases

Alias

Hepatic Adenomas, Familial

Hepatic Adenoma, Somatic	Familial Hepatic Adenoma
Familial Liver Cell Adenomas	Liver Cell Adenomas, Familial
Hepatic Adenomas Familial	HEPAF
Ha	Hepatocellular Adenomas
Hepatocellular Adenoma

Diaphragm Disease

Abnormality Of The Diaphragm	Disease Of Diaphragm
Diaphragmatic Disorder	Disorder Of Diaphragm

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia	Diaphragmatic Hernia
Cdh	Congenital Diaphragmatic Defect
Hernia, Diaphragmatic	Dih
Hernia, Congenital Diaphragmatic	Hcd
Diaphragmatic Defect, Congenital	Diaphragm, Unilateral Agenesis Of
Hemidiaphragm, Agenesis Of	Diaphragmatic Hernia 1
Agenesis Of Hemidiaphragm	Unilateral Agenesis Of Diaphragm
Hernia Diaphragmatic	Hernia Diaphragmatic Congenital
Hernia, Diaphragmatic, Type 1	Hiatus Hernia
Oesophageal Hiatus Hernia	Paraoesophageal Hernia
Sliding Hiatus Hernia	Congenital Diaphragm Hernia
Congenital Diaphragm Defect With Hernia	Gross Congenital Diaphragm Defect

Vesicoureteral Reflux

Vesico-Ureteral Reflux

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13372	SLIT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLIT3	VGNC	VGNC:34961
Canis familiaris	SLIT3	VGNC	VGNC:46505
Rattus norvegicus	SLIT3	RGD	RGD:69311
Mus musculus	SLIT3	MGD	MGI:1315202
Macaca mulatta	SLIT3	VGNC	VGNC:77645
Felis catus	SLIT3	VGNC	VGNC:65453

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