PHACTR4 - phosphatase and actin regulator 4 Gene

Homo sapiens

Also known as PPP1R124

Gene ID: 65979 | Gene type: protein coding

About PHACTR4

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,369,740-28,500,364 (from NCBI)

This gene has 9 transcripts (splice variants), 291 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 8.8), thyroid (RPKM 5.5) and 25 other tissues.

Summary

This gene encodes a member of the Phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein Phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PHACTR4 Products(6)

mRNA	Protein	Name
NM_001048183.3	NP_001041648.1	phosphatase and actin regulator 4 isoform 1
NM_001350158.2	NP_001337087.1	phosphatase and actin regulator 4 isoform 3
NM_001350159.2	NP_001337088.1	phosphatase and actin regulator 4 isoform 3
NM_001350160.2	NP_001337089.1	phosphatase and actin regulator 4 isoform 1
NM_001350161.2	NP_001337090.1	phosphatase and actin regulator 4 isoform 4
NM_023923.4	NP_076412.3	phosphatase and actin regulator 4 isoform 2

PHACTR4 Protein Structure

RPEL

0
200
400
600
702 a.a.

Protein Preferred Names

Protein Names

phosphatase and actin regulator 4

protein phosphatase 1, regulatory subunit 124

Related Diseases

Diseases

Alias

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10405	PHACTR4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PHACTR4	VGNC	VGNC:32806
Canis familiaris	PHACTR4	VGNC	VGNC:44475
Mus musculus	PHACTR4	MGD	MGI:2140327
Macaca mulatta	PHACTR4	VGNC	VGNC:75864
Felis catus	PHACTR4	VGNC	VGNC:107598
Rattus norvegicus	PHACTR4	RGD	RGD:1592823

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