2. Gene
  3. AACS - acetoacetyl-CoA synthetase Gene

AACS - acetoacetyl-CoA synthetase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACSF1; SUR-5

Gene ID: 65985 | Gene type: protein coding

About AACS

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:125,065,435-125,143,316 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues and 13 paralogues. Ubiquitous expression in fat (RPKM 23.3), skin (RPKM 16.5) and 24 other tissues.

Summary

Predicted to enable acetoacetate-CoA Ligase activity. Predicted to be involved in positive regulation of Insulin secretion. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

AACS Products(7)

mRNA Protein Name
NM_001319839.2 NP_001306768.1 acetoacetyl-CoA synthetase isoform 2
NM_001319840.2 NP_001306769.1 acetoacetyl-CoA synthetase isoform 3
NM_001414675.1 NP_001401604.1 acetoacetyl-CoA synthetase isoform 4
NM_001414676.1 NP_001401605.1 acetoacetyl-CoA synthetase isoform 5
NM_001414677.1 NP_001401606.1 acetoacetyl-CoA synthetase isoform 6
NM_001414678.1 NP_001401607.1 acetoacetyl-CoA synthetase isoform 7
NM_023928.5 NP_076417.2 acetoacetyl-CoA synthetase isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AACS Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (109 - 544)

  • 0
  • 200
  • 400
  • 600
  • 672 a.a.
Protein Preferred Names Protein Names

acetoacetyl-CoA synthetase

acetoacetate-CoA ligase

AACS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AACS Q86V21 CMTM5 Homo sapiens Q96DZ9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AACS Proteins

Cat. No. Product Name Accession Purity
HY-P74435 AACS Protein, Human (sf9, His) Q86V21-1 (M1-F672) ≥95%

Related Diseases

Diseases Alias
Atrial Septal Defect 8

ASD8

Atrial Heart Septal Defect 8

Septal Defect, Atrial, Type 8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0124 Zonisamide Inhibitor 99.85% Yes
HY-B0124A Zonisamide sodium Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14880B Bavisant dihydrochloride hydrate Antagonist 99.26% Phase 2
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-161886 SMARCA2-IN-7 / Unkown
HY-161887 SMARCA2-IN-8 Inhibitor / Unkown
HY-RS00016 AACS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AACS VGNC VGNC:37403
Mus musculus AACS MGD MGI:1926144
Rattus norvegicus AACS RGD RGD:708522
Felis catus AACS VGNC VGNC:59448
Bos taurus AACS VGNC VGNC:25438
Macaca mulatta AACS VGNC VGNC:97730
Others AACS NCBI