Bavisant dihydrochloride hydrate (Synonyms: JNJ31001074AAC; JNJ31001074 dihydrochloride hydrate)

Cat. No.: HY-14880B Purity: 99.26%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H₃ receptor. Bavisant dihydrochloride hydrate can be used for attention-deficit hyperactivity disorder (ADHD) research.

For research use only. We do not sell to patients.

Bavisant dihydrochloride hydrate Chemical Structure

CAS No. : 1103522-80-0

Size	Price	Stock	Quantity
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Other Forms of Bavisant dihydrochloride hydrate:

Bavisant Get quote
Bavisant dihydrochloride Get quote

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View All Histamine Receptor Isoform Specific Products:

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

H₃ receptor

In Vivo

Bavisant dihydrochloride hydrate increases acetylcholine levels in rat frontal cortex^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

420.37

Formula

C₁₉H₃₁Cl₂N₃O₃

CAS No.

1103522-80-0

Appearance

Solid

Color

White to pink

SMILES

O=C(N1CCN(C2CC2)CC1)C(C=C3)=CC=C3CN4CCOCC4.[H]Cl.[H]Cl.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (118.94 mM)

DMSO : ≥ 1 mg/mL (2.38 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3789 mL	11.8943 mL	23.7886 mL
5 mM	0.4758 mL	2.3789 mL	4.7577 mL
10 mM	0.2379 mL	1.1894 mL	2.3789 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (118.94 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.26%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (247 KB) HNMR (254 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Hudkins RL, et al. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. J Med Chem. 2011 Jul 14;54(13):4781-92. [Content Brief]

[2]. Weisler RH, et al. Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34. [Content Brief]

[3]. Ghoshal A, et al. Identification of novel β-lactams and pyrrolidinone derivatives as selective Histamine-3 receptor (H3R) modulators as possible anti-obesity agents. Eur J Med Chem. 2018 May 25;152:148-159. [Content Brief]

[4]. Ghamari N, et al. Histamine H3 receptor antagonists/inverse agonists: Where do they go? Pharmacol Ther. 2019 Aug;200:69-84. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.3789 mL	11.8943 mL	23.7886 mL	59.4714 mL
H₂O	5 mM	0.4758 mL	2.3789 mL	4.7577 mL	11.8943 mL
	10 mM	0.2379 mL	1.1894 mL	2.3789 mL	5.9471 mL
	15 mM	0.1586 mL	0.7930 mL	1.5859 mL	3.9648 mL
	20 mM	0.1189 mL	0.5947 mL	1.1894 mL	2.9736 mL
	25 mM	0.0952 mL	0.4758 mL	0.9515 mL	2.3789 mL
	30 mM	0.0793 mL	0.3965 mL	0.7930 mL	1.9824 mL
	40 mM	0.0595 mL	0.2974 mL	0.5947 mL	1.4868 mL
	50 mM	0.0476 mL	0.2379 mL	0.4758 mL	1.1894 mL
	60 mM	0.0396 mL	0.1982 mL	0.3965 mL	0.9912 mL
	80 mM	0.0297 mL	0.1487 mL	0.2974 mL	0.7434 mL
	100 mM	0.0238 mL	0.1189 mL	0.2379 mL	0.5947 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bavisant dihydrochloride hydrate Related Classifications

Neurological Disease Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bavisant dihydrochloride1103522-80-0JNJ31001074AACJNJ31001074 dihydrochlorideHistamine ReceptorwakefulnesscognitionNeurological disordersattention-deficit hyperactivity disorderADHDInhibitorinhibitorinhibit

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