2. Gene
  3. LYNX1 - Ly6/neurotoxin 1 Gene

LYNX1 - Ly6/neurotoxin 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 66004 | Gene type: protein coding

About LYNX1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,771,197-142,777,872 (from NCBI)

This gene has 7 transcripts (splice variants), 103 orthologues and 1 paralogue. Broad expression in brain (RPKM 28.8), heart (RPKM 21.3) and 18 other tissues.

Summary

This gene encodes a GPI-anchored, cell membrane bound member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This protein interacts with nicotinic acetylcholine receptors (nAChRs), and is thought to function as a modulator of nAChR activity to prevent excessive excitation. Alternatively spliced transcript variants have been found for this gene. Read-through transcription between this gene and the neighboring downstream gene (SLURP2) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017]

LYNX1 Products(4)

mRNA Protein Name
NM_001356370.1 NP_001343299.1 ly-6/neurotoxin-like protein 1 precursor
NM_177457.5 NP_803252.1 ly-6/neurotoxin-like protein 1 precursor
NM_177476.4 NP_803429.1 ly-6/neurotoxin-like protein 1 precursor
NM_177477.4 NP_803430.1 ly-6/neurotoxin-like protein 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables acetylcholine receptor binding IDA
IDA: Inferred from direct assay
21252236 GOA
enables acetylcholine receptor regulator activity IDA
IDA: Inferred from direct assay
21252236 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of neurotransmitter receptor activity IDA
IDA: Inferred from direct assay
21252236 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LYNX1 Protein Structure

UPAR_LY6

UPAR_LY6: u-PAR/Ly-6 domain (23 - 53)

UPAR_LY6

UPAR_LY6: u-PAR/Ly-6 domain (59 - 129)

  • 0
  • 100
  • 131 a.a.
Protein Preferred Names Protein Names

ly-6/neurotoxin-like protein 1

Ly-6 neurotoxin-like protein 1

Related Diseases

Diseases Alias
Mal De Meleda

Meleda Disease

Keratosis Palmoplantaris Transgrediens Of Siemens

MDM

Transgrediens Palmoplantar Keratoderma Of Siemens

Acroerythrokeratoderma

Keratosis Palmoplantaris Transgradiens Of Siemens
Psoriasis
Amblyopia

Lazy Eye
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07914 LYNX1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LYNX1 MGD MGI:1345180
Rattus norvegicus LYNX1 RGD RGD:1312017
Bos taurus LYNX1 VGNC VGNC:108094