SMARCD3 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Gene

Homo sapiens

Also known as Rsc6p; BAF60C; CRACD3

Gene ID: 6604 | Gene type: protein coding

About SMARCD3

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,238,780-151,277,149 (from NCBI)

This gene has 15 transcripts (splice variants), 225 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 23.8), heart (RPKM 18.1) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

SMARCD3 Products(3)

mRNA	Protein	Name
NM_001003801.2	NP_001003801.1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 2
NM_001003802.2	NP_001003802.1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 1
NM_003078.4	NP_003069.2	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	14701856	GOA
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	14701856	GOA
enables nuclear receptor coactivator activity	IMP IMP: Inferred from mutant phenotype	17363140	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14701856	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	14701856	GOA
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	14701856	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	11726552	GOA
involved in neural retina development	IEP IEP: Inferred from expression pattern	18816825	GOA
involved in nucleosome disassembly	IDA IDA: Inferred from direct assay	8895581	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14701856	GOA
involved in positive regulation of neuroblast proliferation	IDA IDA: Inferred from direct assay	18816825	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17363140	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SWI/SNF complex	IDA IDA: Inferred from direct assay	8804307	GOA
located in chromatin	IDA IDA: Inferred from direct assay	17363140	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17363140	GOA
part of npBAF complex	IDA IDA: Inferred from direct assay	18816825	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14701856	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMARCD3 Protein Structure

SWIB

0
100
200
300
400
483 a.a.

Protein Preferred Names

Protein Names

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

60 kDa BRG-1/Brm-associated factor subunit C

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13414	SMARCD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SMARCD3	RGD	RGD:1311869
Bos taurus	SMARCD3	VGNC	VGNC:34995
Macaca mulatta	SMARCD3	VGNC	VGNC:77655
Canis familiaris	SMARCD3	VGNC	VGNC:46539
Felis catus	SMARCD3	VGNC	VGNC:65473
Mus musculus	SMARCD3	MGD	MGI:1914243

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