2. Gene
  3. SQLE - squalene epoxidase Gene

SQLE - squalene epoxidase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 6713 | Gene type: protein coding

About SQLE

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:124,998,505-125,022,283 (from NCBI)

This gene has 6 transcripts (splice variants) and 213 orthologues. Broad expression in testis (RPKM 28.6), esophagus (RPKM 19.3) and 22 other tissues.

Summary

Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting Enzymes in this pathway. [provided by RefSeq, Jul 2008]

SQLE Products(1)

mRNA Protein Name
NM_003129.4 NP_003120.2 squalene monooxygenase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables FAD binding IDA
IDA: Inferred from direct assay
30626872 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29765154 GOA
enables squalene monooxygenase activity IDA
IDA: Inferred from direct assay
30626872 GOA
Biological Process GO Annotation Evidence Reference Source
involved in lipid droplet formation IMP
IMP: Inferred from mutant phenotype
29765154 GOA
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
29765154 GOA
involved in sterol biosynthetic process IDA
IDA: Inferred from direct assay
30626872 GOA
Cellular Component GO Annotation Evidence Reference Source
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
30626872 GOA
located in membrane IDA
IDA: Inferred from direct assay
30626872 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SQLE Protein Structure

Pyr_redox

Pyr_redox: Pyridine nucleotide-disulphide oxidoreductase (126 - 154)

SE

SE: Squalene epoxidase (277 - 548)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 574 a.a.
Protein Preferred Names Protein Names

squalene monooxygenase

SE

SQLE Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SQLE Q14534 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SQLE Q14534 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SQLE Q14534 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SQLE Q14534 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
SQLE Q14534 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
SQLE Q14534 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
SQLE Q14534 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
SQLE Q14534 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
SQLE Q14534 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tinea Corporis

Dermatophytosis Of The Body

Dermatophytosis Of The Trunk
Tinea Cruris

Dermatophytosis Of Groin & Perianal Area

Dermatophytosis Of Groin And Perianal Area

Dhobie Itch

Tinea Of Perianal Region
Tinea Pedis

Athlete'S Foot

Dermatophytosis Of Foot

Ringworm Of Foot

Moccasin Foot
Tinea Unguium

Dermatophytosis Of Nail

Onychomycosis Due To Dermatophyte

Cellulitis And Abscess

Cellulitis And Abscess Of Buttock

Cellulitis And Abscess Of Face

Cellulitis And Abscess Of Finger

Cellulitis And Abscess Of Finger And Toe

Cellulitis And Abscess Of Gluteal Region

Cellulitis And Abscess Of Trunk

Cellulitis And Abscess Of Upper Arm And Forearm

Dermatophytic Onychia

Dermatophytic Onychomycosis

Onychomycosis

Ringworm Of Nails

Tinea Of Nail
Tinea Capitis

Dermatophytosis Of Scalp

Scalp Ringworm

Dermatophytosis Of Scalp Or Beard

Tinea Capitis Due To Trichophyton Rubrum

Trichophyton Rubrum Tinea Capitis
Tinea Manuum

Tinea Manus

Dermatophytosis Of Hand
Dermatophytosis

Tinea

Dermatophytosis, Unspecified

Ringworm

Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

Cutaneous Mycosis

Dermal Mycosis

Superficial Mycosis, Unspecified

Fungus Infection Of Skin

Skin Mycosis

Dermatitis Fungoid

Fungal Dermatitis

Fungal Dermatosis

Mycotic Infection Of Skin
Candida Glabrata

Torulopsis Glabrata
Tinea Barbae

Dermatophytosis Of Beard
Humeroradial Synostosis

Humero-Radial Fusion

Humero-Radial Synostosis

Ramer Ladda Syndrome
Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection
Antley-Bixler Syndrome

Trapezoidocephaly Synostosis Syndrome

Trapezoidocephaly-Synostosis Syndrome

Antley Bixler Syndrome

Multisynostotic Osteodysgenesis With Long Bone Fractures

Osteodysgenesis, Multisynostotic With Fractures

Antley-Bixler Syndrome, Autosomal Dominant

Antley-Bixler Syndrome Phenotype
Smith-Lemli-Opitz Syndrome

SLOS

Rsh Syndrome

7-Dehydrocholesterol Reductase Deficiency

Slo Syndrome

Rutledge Lethal Multiple Congenital Anomaly Syndrome

Lethal Acrodysgenital Syndrome

Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung

Smith-Opitz-Inborn Syndrome

Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung

Smith Lemli Opitz Syndrome

Smith-Lemli-Opitz Syndrome, Type Ii
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-160093 SQLE-IN-1 98.82% Unkown
HY-RS13743 SQLE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SQLE VGNC VGNC:77875
Felis catus SQLE VGNC VGNC:65668
Rattus norvegicus SQLE RGD RGD:3755
Mus musculus SQLE MGD MGI:109296
Canis familiaris SQLE VGNC VGNC:46786
Bos taurus SQLE VGNC VGNC:35264