SSR1 - signal sequence receptor subunit 1 Gene

Homo sapiens

Also known as TRAPA

Gene ID: 6745 | Gene type: protein coding

About SSR1

Cytogenetic location: 6p24.3 Genomic coordinates (GRCh38): 6:7,281,143-7,313,199 (from NCBI)

This gene has 11 transcripts (splice variants) and 235 orthologues. Ubiquitous expression in thyroid (RPKM 19.2), appendix (RPKM 16.5) and 25 other tissues.

Summary

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

SSR1 Products(2)

mRNA	Protein	Name
NM_001292008.2	NP_001278937.1	translocon-associated protein subunit alpha isoform 2 precursor
NM_003144.5	NP_003135.2	translocon-associated protein subunit alpha isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17380188	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSR1 Protein Structure

TRAP_alpha

0
100
200
286 a.a.

Protein Preferred Names

Protein Names

translocon-associated protein subunit alpha

SSR alpha subunit

SSR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SSR1	P43307	CANX	Homo sapiens	P27824	Anti Bait CoIP	22314232
Intra	SSR1	P43307	SERPINA1	Homo sapiens	P01009	Anti Bait CoIP	17380188

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SSR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77493	Somatostatin R1/SSR1 Protein, Human (HEK293, Fc)	P43307-1/NP_003135.2 (V19-T207)	≥95%

Related Diseases

Diseases

Alias

Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

Benign Pleural Mesothelioma

Mesothelioma Of Pleura	Benign Neoplasm Of Mesothelial Tissue Of Pleura
Pleural Malignant Mesothelioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13814	SSR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SSR1	VGNC	VGNC:35319
Rattus norvegicus	SSR1	RGD	RGD:1310961
Mus musculus	SSR1	MGD	MGI:105082
Felis catus	SSR1	VGNC	VGNC:65708
Macaca mulatta	SSR1	VGNC	VGNC:77888
Canis familiaris	SSR1	VGNC	VGNC:46837
Others	SSR1	NCBI

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