Slc39a8 - solute carrier family 39 (metal ion transporter), member 8 Gene

Mus musculus

Also known as Zip8; ZIP-8; BIGM103; 4933419D20Rik

Gene ID: 67547 | Gene type: protein coding

About Slc39a8

Summary

Enables anion:cation symporter activity and transition metal ion transmembrane transporter activity. Involved in bicarbonate transport; cellular transition metal ion homeostasis; and ion transmembrane transport. Acts upstream of or within cadmium ion transmembrane transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; metanephros; and reproductive system. Used to study left ventricular noncompaction. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIn. Orthologous to human SLC39A8 (solute carrier family 39 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc39a8 Products(3)

mRNA	Protein	Name
NM_001135149.1	NP_001128621.1	metal cation symporter ZIP8 precursor
NM_001135150.1	NP_001128622.1	metal cation symporter ZIP8 precursor
NM_026228.5	NP_080504.3	metal cation symporter ZIP8 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoatomic cation:bicarbonate symporter activity	IDA IDA: Inferred from direct assay	16638970	MGI
enables zinc:bicarbonate symporter activity	IDA IDA: Inferred from direct assay	18037372	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24529376	MGI
acts upstream of arginine metabolic process	IMP IMP: Inferred from mutant phenotype	28481222	MGI
involved in bicarbonate transport	IDA IDA: Inferred from direct assay	16638970	MGI
acts upstream of or within cadmium ion transmembrane transport	IDA IDA: Inferred from direct assay	15722412	MGI
involved in cadmium ion transmembrane transport	IDA IDA: Inferred from direct assay	16638970	MGI
involved in cadmium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	30015240	MGI
acts upstream of cartilage homeostasis	IMP IMP: Inferred from mutant phenotype	24529376	MGI
acts upstream of extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	29337306	MGI
involved in intracellular manganese ion homeostasis	IMP IMP: Inferred from mutant phenotype	28481222	MGI
involved in intracellular zinc ion homeostasis	IDA IDA: Inferred from direct assay	24529376	MGI
involved in iron ion import across plasma membrane	IDA IDA: Inferred from direct assay	22898811	MGI
involved in iron ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	30015240	MGI
acts upstream of leukocyte adhesion to arterial endothelial cell	IMP IMP: Inferred from mutant phenotype	30015240	MGI
involved in manganese ion transmembrane transport	IDA IDA: Inferred from direct assay	16638970	MGI
involved in manganese ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	28481222	MGI
involved in mercury ion transport	IDA IDA: Inferred from direct assay	16638970	MGI
involved in plasma membrane selenite transport	IDA IDA: Inferred from direct assay	27166256	MGI
acts upstream of protein N-linked glycosylation	IMP IMP: Inferred from mutant phenotype	28481222	MGI
acts upstream of regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	29337306	MGI
involved in zinc ion import across plasma membrane	IDA IDA: Inferred from direct assay	18037372	MGI
involved in zinc ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	29337306	MGI
involved in zinc ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	24529376	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16638970	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15722412	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

metal cation symporter ZIP8

Zrt- and Irt-like protein 8

zinc transporter ZIP8

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16232	Slc39a8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13239	SLC39A8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc39a8	NCBI	NCBI:64116

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