SULT2A1 - sulfotransferase family 2A member 1 Gene

Homo sapiens

Also known as HST; ST2; STD; hSTa; DHEAS; ST2A1; ST2A3; DHEA-ST; SULT2A3; DHEA-ST8

Gene ID: 6822 | Gene type: protein coding

About SULT2A1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:47,870,467-47,886,315 (from NCBI)

This gene has 1 transcript (splice variant), 781 orthologues and 12 paralogues. Biased expression in liver (RPKM 300.0), adrenal (RPKM 86.0) and 2 other tissues.

Summary

This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of Steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]

SULT2A1 Products(1)

mRNA	Protein	Name
NM_003167.4	NP_003158.2	sulfotransferase 2A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-phosphoadenosine 5'-phosphosulfate binding	IDA IDA: Inferred from direct assay	10854859	GOA
enables alcohol sulfotransferase activity	IDA IDA: Inferred from direct assay	7854148	GOA
enables bile-salt sulfotransferase activity	IDA IDA: Inferred from direct assay	1588921	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA
enables steroid sulfotransferase activity	IDA IDA: Inferred from direct assay	23207770	GOA
enables steroid sulfotransferase activity	IMP IMP: Inferred from mutant phenotype	29671343	GOA
enables sulfotransferase activity	IDA IDA: Inferred from direct assay	19548878	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA IDA: Inferred from direct assay	23207770	GOA
involved in cholesterol metabolic process	IDA IDA: Inferred from direct assay	19589875	GOA
involved in ethanol catabolic process	IDA IDA: Inferred from direct assay	23207770	GOA
involved in steroid metabolic process	IDA IDA: Inferred from direct assay	1588921	GOA
involved in steroid metabolic process	IMP IMP: Inferred from mutant phenotype	29671343	GOA
acts upstream of or within sulfation	IDA IDA: Inferred from direct assay	19548878	GOA
involved in sulfation	IDA IDA: Inferred from direct assay	20056724	GOA
involved in thyroid hormone metabolic process	IDA IDA: Inferred from direct assay	10199779	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	7854148	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	2268288	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT2A1 Protein Structure

Sulfotransfer_1

0
100
200
285 a.a.

Protein Preferred Names

Protein Names

sulfotransferase 2A1

alcohol/hydroxysteroid sulfotransferase

Recombinant SULT2A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71343	SULT2A1 Protein, Human (His)	Q06520 (S2-E285)	≥95%

Related Diseases

Diseases

Alias

Mixed Epithelial Stromal Tumour

Adrenal Cortical Adenoma

Adrenocortical Adenoma

Adenoma Adrenocortical

Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome	Pcos
Polycystic Ovarian Disease	Polycystic Ovaries
Stein-Leventhal Syndrome	Multicystic Ovaries
Polycystic Ovary	Sclerocystic Ovaries
Sclerocystic Ovary Syndrome	Stein-Leventhal Synd.
Cystic Disease Of Ovaries	Cystic Disease Of Ovary
Pco	Pcod
Sclerocystic Ovarian Degeneration	Polycystic Ovary Syndrome, Susceptibility To
Pcos - [Polycystic Ovary Syndrome]	Polycystic Ovary Nos
Pco - [Polycystic Ovary]

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Cushing'S Disease	Adrenal Cortex Adenoma
Corticotroph Pituitary Adenoma	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Cortisone Reductase Deficiency

11-Alpha Beta-Hydroxysteroid Dehydrogenase Type I Deficiency Of	Cortrd
Hsd 11b1 Deficiency

Asperger Syndrome

Asperger Disorder

Asperger Syndrome, Susceptibility To

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma	Adrenal Cortex Carcinoma
Carcinoma Of The Adrenal Cortex	Acc
Adrenocortical Cancer	Carcinoma Adrenocortical

Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma	Adult Hepatoma
Adult Hcc

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

Intrahepatic Cholestasis Of Pregnancy

Recurrent Intrahepatic Cholestasis Of Pregnancy	Gravidic Intrahepatic Cholestasis
Pregnancy-Related Cholestasis	Icp
Pregnancy Related Cholestasis	Cholestasis, Intrahepatic Of Pregnancy
Familial Intrahepatic Cholestasis Of Pregnancy	Familial Recurrent Intrahepatic Cholestasis Of Pregnancy
Ricp	Obstetric Cholestasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14020	SULT2A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14021	SULT2B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SULT2A1	RGD	RGD:621337
Macaca mulatta	SULT2A1	VGNC	VGNC:78053
Others	SULT2A1	NCBI

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