BST1 - bone marrow stromal cell antigen 1 Gene

Homo sapiens

Also known as CD157; cADPR2

Gene ID: 683 | Gene type: protein coding

About BST1

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:15,703,065-15,774,173 (from NCBI)

This gene has 5 transcripts (splice variants), 117 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 14.1), duodenum (RPKM 6.3) and 23 other tissues.

Summary

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]

BST1 Products(1)

mRNA	Protein	Name
NM_004334.3	NP_004325.2	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IDA IDA: Inferred from direct assay	7805847	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8202488	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	15328157	GOA
involved in regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	15328157	GOA
involved in regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	15328157	GOA
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	15328157	GOA
involved in regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	15328157	GOA
involved in regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8941363	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	8202488	GOA
located in uropod	IDA IDA: Inferred from direct assay	15328157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BST1 Protein Structure

Rib_hydrolayse

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

ADP-ribosyl cyclase 2

Recombinant BST1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7791	CD157 Protein, Human (HEK293, His)	Q10588 (G29-K292)	≥95%
HY-P7792	CD157 Protein, Human (HEK293, Fc)	Q10588 (G29-K292)	≥95%

Related Diseases

Diseases

Alias

Paroxysmal Nocturnal Hemoglobinuria

Marchiafava-Micheli Disease	Pnh
Hemoglobinuria, Paroxysmal	Marchiafava-Micheli Syndrome
Paroxysmal Hemoglobinuria Nocturnal	Nocturnal Haemoglobinuria
Nocturnal Paroxysmal Haematuria	Nocturnal Paroxysmal Haemoglobinaemia

Rem Sleep Behavior Disorder

Rapid Eye Movement Sleep Behavior Disorder	Rem Sleep Behaviour Disorder
Rapid Eye Movement Sleep Behaviour Disorder	Rem - [Rapid Eye Movement] Behaviour Disorder

Hemoglobinuria

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01648	BST1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BST1	MGD	MGI:105370
Rattus norvegicus	BST1	RGD	RGD:620344
Felis catus	BST1	VGNC	VGNC:60191
Macaca mulatta	BST1	VGNC	VGNC:70285
Canis familiaris	BST1	VGNC	VGNC:38541
Bos taurus	BST1	VGNC	VGNC:26581
Macaca fascicularis	BST1	NCBI	NCBI:101926698
Others	BST1	NCBI

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