TAF4B - TATA-box binding protein associated factor 4b Gene

Homo sapiens

Also known as SPGF13; TAF2C2; TAFII105

Gene ID: 6875 | Gene type: protein coding

About TAF4B

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:26,226,445-26,391,685 (from NCBI)

This gene has 3 transcripts (splice variants), 184 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in testis (RPKM 5.0), lymph node (RPKM 3.4) and 24 other tissues.

Summary

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

TAF4B Products(2)

mRNA	Protein	Name
NM_001293725.2	NP_001280654.1	transcription initiation factor TFIID subunit 4B isoform 1
NM_005640.3	NP_005631.1	transcription initiation factor TFIID subunit 4B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15601843	GOA
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	10849440	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	29111974	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF4B Protein Structure

TAFH

TAF4

0
200
400
600
800
862 a.a.

Protein Preferred Names

Protein Names

transcription initiation factor TFIID subunit 4B

TAF(II)105

Related Diseases

Diseases

Alias

Spermatogenic Failure 13

SPGF13

Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens	CBAVD
Cavd	Congenital Bilateral Aplasia Of Vas Deferens
Congenital Bilateral Absence Of The Vas Deferens	Congenital Bilateral Agenesis Of Vas Deferens
Absence Of Vas Deferens	Absent Vasa
Congenital Absence Of Vas Deferens	Congenital Aplasia Of Vas Deferens
Absent Vas Deferens	Vas Deferens, Congenital Bilateral Absence

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14170	TAF4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TAF4B	RGD	RGD:1562997
Felis catus	TAF4B	VGNC	VGNC:65932
Bos taurus	TAF4B	VGNC	VGNC:35575
Canis familiaris	TAF4B	VGNC	VGNC:47082
Mus musculus	TAF4B	MGD	MGI:2152345
Macaca mulatta	TAF4B	VGNC	VGNC:78091

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