Hjv - hemojuvelin BMP co-receptor Gene

Mus musculus

Also known as DL-M; Hfe2; Rgmc; hemojuvelin; 2310035L15Rik; 5230400G09Rik

Gene ID: 69585 | Gene type: protein coding

About Hjv

Summary

Enables BMP binding activity and coreceptor activity. Involved in cellular iron ion homeostasis and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including BMP signaling pathway; iron ion homeostasis; and negative regulation of BMP signaling pathway. Located in cell surface and extracellular space. Is expressed in several structures, including gonad; musculature; submandibular gland; trunk mesenchyme; and yolk sac. Used to study hemochromatosis type 2A. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 2A. Orthologous to human HJV (hemojuvelin BMP co-receptor). [provided by Alliance of Genome Resources, Apr 2022]

Hjv Products(1)

mRNA	Protein	Name
NM_027126.4	NP_081402.3	hemojuvelin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BMP binding	IDA IDA: Inferred from direct assay	16604073	MGI
enables BMP binding	IPI IPI: Inferred from physical interaction	16604073	MGI
enables coreceptor activity	IGI IGI: Inferred from genetic interaction	16604073	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IGI IGI: Inferred from genetic interaction	16604073	MGI
acts upstream of or within BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	16604073	MGI
involved in intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	25860887	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	16075058	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	20065295	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25860887	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18997172	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16604073	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19751239	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25860887	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18997172	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19751239	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	14749425	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	14749425	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hemojuvelin

RGM domain family member C	hemochromatosis type 2 (juvenile) (human homolog)
hemochromatosis type 2 protein homolog	hemojuvelin BMP coreceptor
repulsive guidance molecule C

Recombinant Hjv Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78029	RGM-C Protein, Mouse (HEK293, His)	Q7TQ32-1 (G33-A393)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06191	HJV Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hjv	NCBI	NCBI:148738
Macaca fascicularis	Hjv	NCBI	NCBI:102138915

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