THY1 - Thy-1 cell surface antigen Gene

Homo sapiens

Also known as CD90; CDw90

Gene ID: 7070 | Gene type: protein coding

About THY1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,415,476-119,424,985 (from NCBI)

This gene has 10 transcripts (splice variants) and 130 orthologues. Broad expression in brain (RPKM 87.8), kidney (RPKM 58.0) and 16 other tissues.

Summary

This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

THY1 Products(4)

mRNA	Protein	Name
NM_001311160.2	NP_001298089.1	thy-1 membrane glycoprotein isoform 1 preproprotein
NM_001311162.2	NP_001298091.1	thy-1 membrane glycoprotein isoform 1 preproprotein
NM_001372050.1	NP_001358979.1	thy-1 membrane glycoprotein isoform 2 precursor
NM_006288.5	NP_006279.2	thy-1 membrane glycoprotein isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IMP IMP: Inferred from mutant phenotype	18346467	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	15004192	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7513706	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	15004192	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18346467	GOA
involved in positive regulation of cellular extravasation	IDA IDA: Inferred from direct assay	15004192	GOA
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	18346467	GOA
involved in regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	9749990	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	14757759	GOA
located in cell surface	IDA IDA: Inferred from direct assay	9749990	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THY1 Protein Structure

0
100
161 a.a.

Protein Preferred Names

Protein Names

thy-1 membrane glycoprotein

Thy-1 T-cell antigen

THY1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	THY1	P04216	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	THY1	P04216	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	THY1	P04216	APP	Homo sapiens	P05067	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant THY1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74516	Thy1/CD90 Protein, Human (HEK293, His)	P04216 (Q20-C130)	≥95%
HY-P74517	Thy1/CD90 Protein, Human (HEK293, Fc)	P04216 (Q20-C130)	≥95%
HY-P74518	Thy1/CD90 Protein, Human (HEK293)	P04216/NP_006279.2（Q20-C130）	≥95%

Related Diseases

Diseases

Alias

Retinal Artery Occlusion

Retina Artery Narrowing	Retinal Artery Spasm
Spasm Of Ophthalmic Artery	Retinal Spasm
Vasospasm Of Retina

Thymoma

Primary Thymic Epithelial Neoplasm	Primary Thymic Epithelial Tumor
Thymus Neoplasms

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx	Npc
Nasopharyngeal Cancer	Nasopharyngeal Carcinoma 1
Nasopharynx Carcinoma	Nasopharyngeal Neoplasms
Npca	Carcinoma Of Nasopharynx
Malignant Nasopharyngeal Tumor	Nasopharynx Cancer
Squamous Cell Carcinoma Of The Nasopharynx	Nasopharyngeal Neoplasm
Cancer Of Nasopharynx

Mesangial Proliferative Glomerulonephritis

Glomerulonephritis - Mesangial Proliferative	Mesangial Proliferative Gn
Mesangioproliferative Glomerulonephritis	Glomerulonephritis Mesangial Proliferative

Acute Leukemia

Stem Cell Leukaemia	Stem Cell Leukemia
Acute Leukemias	Acute Undifferentiated Leukemia
Undifferentiated Leukemia	Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission
Blast Cell Leukaemia	Blast Leukaemia
Blastic Leukaemia	Undifferentiated Leukaemia

Adhesions Of Uterus

Intrauterine Adhesions	Intrauterine Synechiae
Band Of Uterus	Asherman Syndrome
Internal Adhesion Of Uterus	Internal Band Of Uterus

Anal Fistula

Anorectal Fistula	Rectal Fistula
Allingham Ulcer	Perianal Fistula
Fistula In Ano	Anorectum Fistula

Dental Pulp Disease

Dental Pulp Diseases	Dental Pulp Disorder
Disorder Of Pulp Of Tooth	Pulp Disorder

Dental Pulp Necrosis

Pulp Necrosis	Necrotic Pulp
Necrosis Of The Pulp	Dead Pulp
Devitalised Pulp	Putrescent Pulpitis
Devitalized Tooth	Dental Pulp Gangrene
Pulp Gangrene	Nonvital Tooth
Pulpless Tooth	Putrescent Pulp

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Limb Ischemia

Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm

Tibial Nerve Palsy

Cartilage Disease

Cartilage Diseases	Cartilage
Cartilage Disorder	Chondropathy
Cartilage Disorders

Germ Cell Cancer

Malignant Germ Cell Tumor	Neoplasms, Germ Cell And Embryonal
Germ Cell Neoplasm	Germ Cell Tumour
Malignant Tumor Of The Germ Cell	Neoplasms Germ Cell
Malignant Germ Cell Neoplasm

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Inflammatory Bowel Disease 14

IBD14	Inflammatory Bowel Disease 14, Susceptibility To
Bowel Disease, Inflammatory, Type 14

Spinocerebellar Ataxia 45

SCA45

Spinocerebellar Ataxia Type 45

Brittle Bone Disorder

Osteogenesis Imperfecta	Brittle Bone Disease
Fragilitas Ossium	Osteopsathyrosis
Lobstein Disease	Oi
Vrolik Disease	Lobstein'S Disease
Lobstein'S Syndrome	Vrolik'S Disease
Porak And Durante Disease	Glass Bone Disease
Osteogenesis Imperfecta, Dominant Perinatal Lethal	Osteogenesis Imperfecta, Recessive Perinatal Lethal
Brittle Bone Syndrome	Oi - [Osteogenesis Imperfecta]
Ossium Fragility	Osteitis Fragilitans
Bony Fragility	Blue Sclera With Fragility Of Bone And Deafness
White Blue Sclera - Fragility Of Bone - Deafness

Epilepsy, Familial Temporal Lobe, 2

Familial Temporal Lobe Epilepsy 2	Temporal Epilepsy, Familial
ETL2	Ftle
Epilepsy, Familial Temporal Lobe	Familial Temporal Lobe Epilepsy

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

Osteochondrodysplasia

Skeletal Dysplasia	Chondrodystrophy
Congenital Anomaly Of Cartilage	Osteochondrodysplasias
Cartilage Development Disorder	Osteochondrodysplasia Syndrome
Dysplasia, Skeletal	Mucopolysaccharidosis Iv

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12953	R-268712	Inhibitor	99.88%	Unkown
HY-106611	Brinazarone	Inhibitor	/	Unkown
HY-RS14511	THY1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	THY1	VGNC	VGNC:78352
Rattus norvegicus	THY1	RGD	RGD:3860
Felis catus	THY1	VGNC	VGNC:104334
Canis familiaris	THY1	VGNC	VGNC:47362
Mus musculus	THY1	MGD	MGI:98747
Bos taurus	THY1	VGNC	VGNC:35856
Macaca fascicularis	THY1	NCBI	NCBI:102139037
Others	THY1	NCBI