TLE2 - TLE family member 2, transcriptional corepressor Gene

Homo sapiens

Also known as ESG; ESG2; GRG2

Gene ID: 7089 | Gene type: protein coding

About TLE2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,997,644-3,047,635 (from NCBI)

This gene has 22 transcripts (splice variants), 103 orthologues and 6 paralogues. Ubiquitous expression in salivary gland (RPKM 17.9), fat (RPKM 13.6) and 24 other tissues.

Summary

Enables transcription corepressor activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription, DNA-templated. Located in focal adhesion and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

TLE2 Products(4)

mRNA	Protein	Name
NM_001144761.2	NP_001138233.1	transducin-like enhancer protein 2 isoform 2
NM_001144762.2	NP_001138234.1	transducin-like enhancer protein 2 isoform 3
NM_001300846.2	NP_001287775.1	transducin-like enhancer protein 2 isoform 4
NM_003260.5	NP_003251.2	transducin-like enhancer protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17041588	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	19460168	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19460168	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	19460168	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLE2 Protein Structure

TLE_N

WD40

0
200
400
600
743 a.a.

Protein Preferred Names

Protein Names

transducin-like enhancer protein 2

enhancer of split groucho-like protein 2

TLE2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TLE2	Q04725	DDB1	Homo sapiens	Q16531	Anti Bait CoIP	17041588

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Bladder	Epidermoid Carcinoma Of The Urinary Bladder
Carcinoma Squamous Cell Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14564	TLE2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TLE2	VGNC	VGNC:49981
Canis familiaris	TLE2	VGNC	VGNC:55001
Mus musculus	TLE2	MGD	MGI:104635
Felis catus	TLE2	VGNC	VGNC:66209
Rattus norvegicus	TLE2	RGD	RGD:1306665
Macaca mulatta	TLE2	VGNC	VGNC:78365

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