CLEC3B - C-type lectin domain family 3 member B Gene

Homo sapiens

Also known as TN; TNA; MCDR4

Gene ID: 7123 | Gene type: protein coding

About CLEC3B

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,026,303-45,036,071 (from NCBI)

This gene has 3 transcripts (splice variants), 251 orthologues and 2 paralogues. Broad expression in spleen (RPKM 63.9), fat (RPKM 63.1) and 20 other tissues.

Summary

Enables calcium ion binding activity; heparin binding activity; and kringle domain binding activity. Involved in bone mineralization and cellular response to transforming growth factor beta stimulus. Located in cytoplasm; extracellular space; and granular component. Part of collagen-containing extracellular matrix. Implicated in osteoarthritis. [provided by Alliance of Genome Resources, Apr 2022]

CLEC3B Products(2)

mRNA	Protein	Name
NM_001308394.2	NP_001295323.1	tetranectin isoform 2
NM_003278.3	NP_003269.2	tetranectin isoform 1precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	9786936	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	10727405	GOA
enables kringle domain binding	IPI IPI: Inferred from physical interaction	9786936	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone mineralization	IDA IDA: Inferred from direct assay	7798325	GOA
involved in ossification	IEP IEP: Inferred from expression pattern	7798325	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	7798325	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	7798325	GOA
located in granular component	IDA IDA: Inferred from direct assay	15848710	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC3B Protein Structure

Lectin_C

0
100
202 a.a.

Protein Preferred Names

Protein Names

tetranectin

plasminogen kringle 4-binding protein

Recombinant CLEC3B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7815	Tetranectin/CLEC3B Protein, Human (181a.a, HEK293, His)	AAH11024.1 (E22-V202)	≥95%

Related Diseases

Diseases

Alias

Macular Dystrophy, Retinal, 4

MCDR4

Ureteric Orifice Cancer

Malignant Neoplasm Of Ureteric Orifice Of Urinary Bladder	Malignant Tumor Of Ureteric Orifice
Orifice Of The Ureter

Osteoarthritis

Osteoarthrosis	Degenerative Joint Disease
Hypertrophic Arthritis	Arthropathy
Degenerative Polyarthritis	Degenerative Arthritis
Osteoarthrosis And Allied Disorder	Arthritis, Degenerative
Oa	Osteoarthritis Deformans
Osteoarthrosis Deformans	Kashin-Beck Disease

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Pelvic Inflammatory Disease

Pid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02790	CLEC3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CLEC3B	VGNC	VGNC:54591
Macaca mulatta	CLEC3B	VGNC	VGNC:110373
Bos taurus	CLEC3B	VGNC	VGNC:27429
Felis catus	CLEC3B	VGNC	VGNC:60950
Rattus norvegicus	CLEC3B	RGD	RGD:1311031
Mus musculus	CLEC3B	MGD	MGI:104540
Others	CLEC3B	NCBI

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