TNFAIP2 - TNF alpha induced protein 2 Gene

Homo sapiens

Also known as B94; EXOC3L3

Gene ID: 7127 | Gene type: protein coding

About TNFAIP2

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:103,121,469-103,137,439 (from NCBI)

This gene has 11 transcripts (splice variants), 271 orthologues and 4 paralogues. Ubiquitous expression in urinary bladder (RPKM 54.5), spleen (RPKM 53.6) and 22 other tissues.

Summary

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]

TNFAIP2 Products(3)

mRNA	Protein	Name
NM_001371220.1	NP_001358149.1	tumor necrosis factor alpha-induced protein 2 isoform 2
NM_001371221.1	NP_001358150.1	tumor necrosis factor alpha-induced protein 2 isoform 2
NM_006291.4	NP_006282.2	tumor necrosis factor alpha-induced protein 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP2 Protein Structure

Sec6

0
200
400
600
654 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor alpha-induced protein 2

exocyst complex component 3-like 3

Related Diseases

Diseases

Alias

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14788	TNFAIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	≥90.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNFAIP2	RGD	RGD:1594556
Canis familiaris	TNFAIP2	VGNC	VGNC:47649
Bos taurus	TNFAIP2	VGNC	VGNC:53955
Felis catus	TNFAIP2	VGNC	VGNC:80817
Mus musculus	TNFAIP2	MGD	MGI:104960
Macaca mulatta	TNFAIP2	VGNC	VGNC:78579

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