TRIO - trio Rho guanine nucleotide exchange factor Gene

Homo sapiens

Also known as tgat; MEBAS; MRD44; MRD63; ARHGEF23

Gene ID: 7204 | Gene type: protein coding

About TRIO

Cytogenetic location: 5p15.2 Genomic coordinates (GRCh38): 5:14,143,342-14,510,204 (from NCBI)

This gene has 27 transcripts (splice variants), 226 orthologues, 22 paralogues and is associated with 4 phenotypes. Ubiquitous expression in brain (RPKM 8.0), spleen (RPKM 6.0) and 25 other tissues.

Summary

This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin Cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

TRIO Products(1)

mRNA	Protein	Name
NM_007118.4	NP_009049.2	triple functional domain protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17043677	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	32109419	GOA
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26858404	GOA
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	26858404	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26858404	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26858404	GOA
is active in presynaptic active zone	IDA IDA: Inferred from direct assay	27907191	GOA
is active in presynaptic active zone	IMP IMP: Inferred from mutant phenotype	27907191	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIO Protein Structure

CRAL_TRIO_2

Spectrin

RhoGEF

SH3_1

RhoGEF

I-set

Pkinase

0
500
1000
1500
2000
2500
3097 a.a.

Protein Preferred Names

Protein Names

triple functional domain protein

PTPRF-interacting protein

TRIO Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRIO	O75962	DISC1	Homo sapiens	Q9NRI5	Y2H	17043677

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 44, With Microcephaly

MRD44	Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome
Autosomal Dominant Non-Syndromic Intellectual Disability 44	Mental Retardation, Autosomal Dominant 44
Autosomal Dominant Intellectual Developmental Disorder 44	Autosomal Dominant Intellectual Developmental Disorder 44 With Microcephaly
Autosomal Dominant Mental Retardation 44	Mental Retardation, Autosomal Dominant, Type 44

Intellectual Developmental Disorder, Autosomal Dominant 63, With Macrocephaly

MRD63

Mental Retardation, Autosomal Dominant 63, With Macrocephaly

Deafness, Autosomal Recessive 28

DFNB28	Autosomal Recessive Nonsyndromic Deafness 28
Autosomal Recessive Deafness 28	Deafness, Autosomal Recessive, 28
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 28	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 28
Deafness, Autosomal Recessive, Type 28

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Gastroesophageal Adenocarcinoma

Gastric And Esophageal Adenocarcinoma

Gastro-Esophageal Adenocarcinoma

Loeys-Dietz Syndrome 2

LDS2	Aat3
Marfan Syndrome Type 2	Aortic Aneurysm, Familial Thoracic 3
Marfan Syndrome Type Ii	Loeys-Dietz Syndrome Type 2
Mfs2	Marfan Syndrome, Type Ii, Formerly
Familial Throacic Aortic Aneurysm 3	Familial Aortic Aneurysm Thoracic Type 3
Taad2	Thoracic Aortic Aneurysms And Dissection 2
Aneurysm, Aortic, Thoracic, Familial, Type 3	Loeys-Dietz Syndrome, Type 2

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16663	ITX3	Inhibitor	98.60%	Unkown
HY-N1783	(24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid	Inhibitor	/	Unkown
HY-RS15074	TRIO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIO	MGD	MGI:1927230
Canis familiaris	TRIO	VGNC	VGNC:47842
Rattus norvegicus	TRIO	RGD	RGD:1308360
Bos taurus	TRIO	VGNC	VGNC:36356
Macaca mulatta	TRIO	VGNC	VGNC:84509
Macaca fascicularis	TRIO	NCBI	NCBI:102115266
Others	TRIO	NCBI

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