TRO - trophinin Gene

Homo sapiens

Also known as MAGED3; MAGE-d3

Gene ID: 7216 | Gene type: protein coding

About TRO

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:54,920,824-54,931,431 (from NCBI)

This gene has 25 transcripts (splice variants), 162 orthologues and 37 paralogues. Broad expression in ovary (RPKM 9.7), brain (RPKM 9.7) and 20 other tissues.

Summary

This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in Cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

TRO Products(6)

mRNA	Protein	Name
NM_001039705.3	NP_001034794.1	trophinin isoform 5
NM_001271183.2	NP_001258112.1	trophinin isoform 6
NM_001271184.2	NP_001258113.1	trophinin isoform 7
NM_016157.4	NP_057241.2	trophinin isoform 2
NM_177556.3	NP_808224.1	trophinin isoform 2
NM_177557.3	NP_808225.1	trophinin isoform 4

TRO Protein Structure

MAGE

0
300
600
900
1200
1431 a.a.

Protein Preferred Names

Protein Names

trophinin

MAGE superfamily protein

Related Diseases

Diseases

Alias

Ectopic Pregnancy

Eccyesis	Pregnancy Ectopic
Pregnancy, Ectopic	Ectopic Pregnancies
Extrauterine Gestation Or Pregnancy	Extrauterine Pregnancy
Ep - [Ectopic Pregnancy]	Ectopic Mole
Aborted Ectopic Pregnancy	Ruptured Ectopic Pregnancy

Dysbaric Osteonecrosis

Caisson Disease Of Bone

Don

Crouzon Syndrome With Acanthosis Nigricans

Crouzon Syndrome-Acanthosis Nigricans Syndrome	CAN
Crouzonodermoskeletal Syndrome	Crouzon-Dermoskeletal Syndrome
Crouzon, With Acanthosis Nigricans Syndrome

Hermansky-Pudlak Syndrome 3

HPS3	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 3
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Combat Disorder

Combat Disorders

Combat Neurosis

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Secondary Syphilis

Syphilis, Secondary

Secondary Syphilis Of Viscera Or Bone

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14796	Olesoxime	Inhibitor	99.09%	Phase 3

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-154848	UCL-TRO-1938	Activator	99.98%	Unkown
HY-RS15100	TRO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRO	MGD	MGI:1928994
Rattus norvegicus	TRO	RGD	RGD:6488256
Bos taurus	TRO	VGNC	VGNC:108180
Canis familiaris	TRO	NCBI	NCBI:612655
Macaca fascicularis	TRO	NCBI	NCBI:102136335
Susscrofa domestica	TRO	NCBI
Macaca mulatta	TRO	NCBI
Others	TRO	NCBI

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