Rps6kb1 - ribosomal protein S6 kinase, polypeptide 1 Gene

Mus musculus

Also known as S6K; S6K1; p70s6k; P70S6K1; p70 S6KA; p70-S6K 1; p70/85s6k; S6K-beta-1; 2610318I15Rik; p70 S6K-alpha

Gene ID: 72508 | Gene type: protein coding

About Rps6kb1

Chromosome 11: 86,389,697-86,435,631 reverse strand.GRCm39:CM001004.3

This gene has 7 transcripts (splice variants), 155 orthologues, 7 paralogues and is associated with 25 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 5.), limb E14.5 (RPKM 4.8) and 26 other tissues.

Summary

Enables protein kinase activity. Involved in several processes, including cellular response to interferon-gamma; long-chain fatty acid import into cell; and peptidyl-serine phosphorylation. Acts upstream of or within several processes, including behavioral fear response; cellular response to hormone stimulus; and protein kinase B signaling. Located in mitochondrion. Is expressed in several structures, including central nervous system; early conceptus; olfactory epithelium; reproductive system; and retina nuclear layer. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Apr 2022]

Rps6kb1 Products(3)

mRNA	Protein	Name
NM_001363162.1	NP_001350091.1	ribosomal protein S6 kinase beta-1 isoform 3
NM_028259.4	NP_082535.1	ribosomal protein S6 kinase beta-1 isoform 2
NM_001114334.2	NP_001107806.1	ribosomal protein S6 kinase beta-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20657550	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	15249583	MGI
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	15249583	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within behavioral fear response	IGI IGI: Inferred from genetic interaction	24990923	MGI
acts upstream of or within cellular response to dexamethasone stimulus	IDA IDA: Inferred from direct assay	17556672	MGI
acts upstream of or within cellular response to insulin stimulus	IGI IGI: Inferred from genetic interaction	24349514	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	24990923	MGI
involved in cellular response to type II interferon	IMP IMP: Inferred from mutant phenotype	28178239	MGI
acts upstream of or within germ cell development	IDA IDA: Inferred from direct assay	12140361	MGI
involved in long-chain fatty acid import into cell	IMP IMP: Inferred from mutant phenotype	28178239	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	18174371	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	18174371	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11493700	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	11493700	MGI
acts upstream of or within negative regulation of insulin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15249583	MGI
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	28178239	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	15249583	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15249583	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18174371	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18174371	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	11493700	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rps6kb1 Protein Structure

STKc_p70S6K

0
100
200
300
400
525 a.a.

Protein Preferred Names

Protein Names

ribosomal protein S6 kinase beta-1

70 kDa ribosomal protein S6 kinase 1	p70 S6 kinase alpha
p70 ribosomal S6 kinase alpha	ribosomal protein S6 kinase I
ribosomal protein S6 kinase, 70kD, polypeptide 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148062	RSS0680		98.03%	Unkown
HY-RS12262	RPS6KB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12263	Rps6kb1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12264	Rps6kb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rps6kb1	NCBI	NCBI:6198

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