TNFRSF4 - TNF receptor superfamily member 4 Gene

Homo sapiens

Also known as OX40; ACT35; CD134; IMD16; TXGP1L

Gene ID: 7293 | Gene type: protein coding

About TNFRSF4

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,211,340-1,214,153 (from NCBI)

This gene has 14 transcripts (splice variants), 451 orthologues, 21 paralogues and is associated with 2 phenotypes. Broad expression in fat (RPKM 2.7), lymph node (RPKM 1.6) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of Apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses Apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

TNFRSF4 Products(2)

mRNA	Protein	Name
NM_001410709.1	NP_001397638.1	tumor necrosis factor receptor superfamily member 4 isoform 2 precursor
NM_003327.4	NP_003318.1	tumor necrosis factor receptor superfamily member 4 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16905106	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF4 Protein Structure

TNFR_c6

0
100
200
277 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 4

ACT35 antigen

Recombinant TNFRSF4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7394	OX40/TNFRSF4 Protein, Human (HEK293, His)	P43489 (L29-A216)	≥95%
HY-P70813	OX40/TNFRSF4 Protein, Human (HEK293, Fc)	P43489 (L29-A216)	≥95%
HY-P72404	OX40/TNFRSF4 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P43489 (L29-A216)	≥95%
HY-P78188	OX40/TNFRSF4 Protein, Human (Biotinylated, HEK293, Fc)	P43489 (L29-A216)	≥95%
HY-P78189	OX40/TNFRSF4 Protein, Human (Biotinylated, HEK293, His-Avi)	P43489 (L29-A216)	≥95%
HY-P78503	OX40/TNFRSF4 Protein, Human (HEK293, His-Avi)	P43489 (L29-A216)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 16

Combined Immunodeficiency Due To Ox40 Deficiency	IMD16
Ox40 Deficiency	Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma
Combined Immunodeficiency With Impaired Immunity To Hhv-8	Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8
Immunodeficiency, Type 16

Kaposi Sarcoma

Kaposi'S Sarcoma	Kaposi Sarcoma, Susceptibility To
Kaposi'S Sarcoma Of Lung	Kaposi'S Sarcoma Of Palate
Kaposi'S Sarcoma Of Soft Tissue	Kaposi'S Sarcoma-Associated Herpesvirus
Multiple Idiopathic Pigmented Hemangiosarcoma	Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To
African Lymphadenopathic Kaposi'S Sarcoma	Anal Kaposi'S Sarcoma
Cardiac Kaposi'S Sarcoma	Central Nervous System Kaposi'S Sarcoma
Conjunctival Kaposi'S Sarcoma	Corneal Kaposi'S Sarcoma
Cutaneous Kaposi'S Sarcoma	Esophageal Kaposi'S Sarcoma
Gallbladder Kaposi'S Sarcoma	Gastric Kaposi'S Sarcoma
Intestinal Kaposi'S Sarcoma	Kaposi'S Sarcoma Of Anus
Kaposi'S Sarcoma Of Central Nervous System	Kaposi'S Sarcoma Of Conjunctiva
Kaposi'S Sarcoma Of Cornea	Kaposi'S Sarcoma Of Esophagus
Kaposi'S Sarcoma Of Gastrointestinal Sites	Kaposi'S Sarcoma Of Heart
Kaposi'S Sarcoma Of Lymph Nodes	Kaposi'S Sarcoma Of Penis
Kaposi'S Sarcoma Of Skin	Kaposi'S Sarcoma Of Soft Tissues
Kaposi'S Sarcoma Of The Cns	Kaposi'S Sarcoma Of The Gallbladder
Kaposi'S Sarcoma Of The Prostate	Kaposi'S Sarcoma, Lung
Kaposi'S Sarcoma, Skin	Lymph Node Kaposi'S Sarcoma
Lymphadenopathic Kaposi'S Sarcoma	Palate Kaposi'S Sarcoma
Penis Kaposi'S Sarcoma	Prostate Kaposi'S Sarcoma
Pulmonary Kaposi'S Sarcoma	Soft Tissue Kaposi'S Sarcoma
Hhv8	Human Herpesvirus 8
Kshv	Kaposi Sarcoma Herpesvirus
Mediterranean Kaposi Sarcoma	Non Aids Related Kaposi Sarcoma
Sarcoma, Kaposi	Sarcoma, Kaposi, Susceptibility To
Non-Aids-Related Kaposi Sarcoma	Angiolymphoid Hyperplasia
Angiofollicular Ganglionic Hyperplasia	Multi-Centric Castleman'S Disease

Myasthenia Gravis

MG	Acquired Myasthenia
Autoimmune Myasthenia Gravis	Erb-Goldflam Disease
Mg - [Myasthenia Gravis]	Myasthenia Gravis Nos
Myasthenia

Nodular Goiter

Goiter, Nodular	Nodular Goitre
Goiter Nodular	Non-Toxic Nodular Goiter

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Lymphoproliferative Syndrome 2

Cd27 Deficiency	LPFS2
Combined Immunodeficiency Due To Cd27 Deficiency	Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Mixed Oligodendroglioma-Astrocytoma

Who Grade Ii Mixed Glioma

Soft Palate Cancer

Malignant Tumor Of Soft Palate	Malignant Tumor Of The Soft Palate
Palate Cancer Soft Palate

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14814	TNFRSF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFRSF4	MGD	MGI:104512
Canis familiaris	TNFRSF4	VGNC	VGNC:47665
Bos taurus	TNFRSF4	VGNC	VGNC:36168
Rattus norvegicus	TNFRSF4	RGD	RGD:3920
Macaca mulatta	TNFRSF4	VGNC	VGNC:106523
Felis catus	TNFRSF4	VGNC	VGNC:66411
Macaca fascicularis	TNFRSF4	NCBI	NCBI:102145978
Others	TNFRSF4	NCBI

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