UCP2 - uncoupling protein 2 Gene

Homo sapiens

Also known as UCPH; BMIQ4; SLC25A8

Gene ID: 7351 | Gene type: protein coding

About UCP2

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:73,974,672-73,983,202 (from NCBI)

This gene has 11 transcripts (splice variants), 193 orthologues, 49 paralogues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 136.6), spleen (RPKM 105.7) and 20 other tissues.

Summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate Oxidative Phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]

UCP2 Products(8)

mRNA	Protein	Name
NM_001381943.1	NP_001368872.1	mitochondrial uncoupling protein 2 isoform a
NM_001381944.1	NP_001368873.1	mitochondrial uncoupling protein 2 isoform a
NM_001381945.1	NP_001368874.1	mitochondrial uncoupling protein 2 isoform a
NM_001381947.1	NP_001368876.1	mitochondrial uncoupling protein 2 isoform a
NM_001381948.1	NP_001368877.1	mitochondrial uncoupling protein 2 isoform a
NM_001381949.1	NP_001368878.1	mitochondrial uncoupling protein 2 isoform b
NM_001381950.1	NP_001368879.1	mitochondrial uncoupling protein 2 isoform c
NM_003355.3	NP_003346.2	mitochondrial uncoupling protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-aspartate transmembrane transporter activity	IDA IDA: Inferred from direct assay	24395786	GOA
enables antiporter activity	IDA IDA: Inferred from direct assay	24395786	GOA
enables chloride transmembrane transporter activity	IDA IDA: Inferred from direct assay	22524567	GOA
enables malate transmembrane transporter activity	IDA IDA: Inferred from direct assay	24395786	GOA
enables oxaloacetate transmembrane transporter activity	IDA IDA: Inferred from direct assay	24395786	GOA
enables phosphate ion uniporter activity	IDA IDA: Inferred from direct assay	24395786	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	26182433	GOA
enables proton transmembrane transporter activity	IDA IDA: Inferred from direct assay	22524567	GOA
enables secondary active sulfate transmembrane transporter activity	IDA IDA: Inferred from direct assay	24395786	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in C4-dicarboxylate transport	IMP IMP: Inferred from mutant phenotype	24395786	GOA
involved in glutamine metabolic process	IMP IMP: Inferred from mutant phenotype	24395786	GOA
involved in glycolytic process	IMP IMP: Inferred from mutant phenotype	24395786	GOA
involved in mitochondrial transmembrane transport	IMP IMP: Inferred from mutant phenotype	24395786	GOA
involved in negative regulation of calcium import into the mitochondrion	IDA IDA: Inferred from direct assay	27642082	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	22292025	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCP2 Protein Structure

Mito_carr

0
100
200
309 a.a.

Protein Preferred Names

Protein Names

mitochondrial uncoupling protein 2

solute carrier family 25 member 8

Related Diseases

Diseases

Alias

Body Mass Index Quantitative Trait Locus 4

Obesity	Obesity, Susceptibility To, Bmiq4
BMIQ4	Obesity, Susceptibility To
Obesity Bmiq4

Hyperinsulinism Due To Ucp2 Deficiency

Hyperinsulinemic Hypoglycemia Due To Ucp2 Deficiency

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Hyperinsulinism

Hyperinsulinemia

Non-Alcoholic Fatty Liver Disease

Fatty Liver	Non-Alcoholic Fatty Liver
Nafld	Nonalcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis	Steatosis
Nafl	Nash
Non-Alcoholic Steatohepatitis	Susceptibility To Nonalcoholic Fatty Liver Disease
Steatohepatitis	Fatty Degeneration
Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis	Nafld Without Nash
Nafld Without Mention Of Nash

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Glucose Intolerance

Glucose: Intolerance	Glucose: Malabsorption
Malabsorption Of Glucose	Impaired Glucose Tolerance

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Prediabetes Syndrome

Prediabetes	Impaired Glucose Tolerance
Prediabetic State	IGT
Igt - [Impaired Glucose Tolerance]	Impaired Glucose Tolerance With Unspecified Complication
Impaired Glucose Tolerance Without Complication	Abnormal Glucose Tolerance

Hyperinsulinemic Hypoglycemia, Familial, 6

Hyperinsulinism-Hyperammonemia Syndrome	HHF6
Familial Hyperinsulinemic Hypoglycemia 6	Hi/Ha Syndrome
Ha/Hi Syndrome	Hyperinsulinemic Hypoglycemia Familial 6
Hyperinsulinism Hyperammonemia Syndrome	Hhs

Hyperinsulinemic Hypoglycemia, Familial, 7

HHF7	Exercise-Induced Hyperinsulinemic Hypoglycemia
Exercise-Induced Hyperinsulinism	Familial Hyperinsulinemic Hypoglycemia 7
Eihi	Hyperinsulinism Due To Monocarboxylate Transporter 1 Deficiency
Hyperinsulinism Due To Slc16a1 Deficiency	Hyperinsulinemic Hypoglycemia, Exercise-Induced
Exercise Induced Hyperinsulinemic Hypoglycemia	Hyperinsulinemic Hypoglycemia Exercise-Induced
Hyperinsulinemic Hypoglycemia Familial 7

Abdominal Obesity-Metabolic Syndrome 1

Metabolic Syndrome X	Metabolic Syndrome
AOMS1	Dysmetabolic Syndrome X
Metabolic Disease	Abdominal Obesity Metabolic Syndrome

Diabetes Mellitus

Diabetes

Hyperinsulinemic Hypoglycemia

Nesidioblastosis	Islet Cell Hyperplasia
Persistent Hyperinsulinemia Hypoglycemia Of Infancy	Hyperinsulinemic Hypoglycaemia

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Cardiomyopathy, Dilated, 1l

Dilated Cardiomyopathy 1l	CMD1L
Cardiomyopathy, Dilated 1l	Cardiomyopathy, Dilated, Type 1l

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17389	Genipin	Inhibitor	99.67%	Phase 3
HY-138830	TAK-418	Inhibitor	99.10%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120160	Darglitazone	Agonist	99.19%	Unkown
HY-120160A	Darglitazone Sodium	Agonist	/	Unkown
HY-RS15411	UCP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UCP2	VGNC	VGNC:78709
Rattus norvegicus	UCP2	RGD	RGD:3932
Felis catus	UCP2	VGNC	VGNC:66799
Mus musculus	UCP2	MGD	MGI:109354
Bos taurus	UCP2	VGNC	VGNC:36641
Canis familiaris	UCP2	VGNC	VGNC:48111

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