2. Gene
  3. Als2 - alsin Rho guanine nucleotide exchange factor Gene

Als2 - alsin Rho guanine nucleotide exchange factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Alsin; Als2cr6; mKIAA1563; 3222402C23Rik; 9430073A21Rik

Gene ID: 74018 | Gene type: protein coding

About Als2

Summary

Predicted to enable several functions, including GTPase regulator activity; protein homodimerization activity; and small GTPase binding activity. Acts upstream of or within several processes, including behavioral fear response; glutamatergic synaptic transmission; and receptor recycling. Located in several cellular components, including centrosome; lamellipodium; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2). [provided by Alliance of Genome Resources, Apr 2022]

Als2 Products(3)

mRNA Protein Name
NM_001159948.2 NP_001153420.2 alsin isoform 1
NM_028717.6 NP_082993.4 alsin isoform 1
NM_146109.3 NP_666221.1 alsin isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17093100 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
16107644 MGI
acts upstream of or within endosomal transport IMP
IMP: Inferred from mutant phenotype
16321985 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
16107644 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
16321985 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
17093100 MGI
acts upstream of or within receptor recycling IMP
IMP: Inferred from mutant phenotype
17093100 MGI
acts upstream of or within regulation of GTPase activity IDA
IDA: Inferred from direct assay
16085057 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: Inferred from direct assay
17093100 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
IEP: Inferred from expression pattern
17093100 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: Inferred from mutant phenotype
17093100 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
16107644 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
17093100 MGI
acts upstream of or within vesicle organization IDA
IDA: Inferred from direct assay
16085057 MGI
Cellular Component GO Annotation Evidence Reference Source
located in centrosome IDA
IDA: Inferred from direct assay
16085057 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16085057 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
17093100 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17093100 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
17093100 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17093100 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
15033976 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
17093100 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17093100 MGI
is active in postsynaptic density IMP
IMP: Inferred from mutant phenotype
17093100 MGI
located in ruffle IDA
IDA: Inferred from direct assay
15033976 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alsin

amyotrophic lateral sclerosis 2 (juvenile) homolog

amyotrophic lateral sclerosis 2 protein homolog

amyotrophic lateral sclerosis protein 2 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00634 ALS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00635 ALS2CL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Als2 NCBI NCBI:57679
Macaca fascicularis Als2 NCBI NCBI:101925534