VEGFB - vascular endothelial growth factor B Gene

Homo sapiens

Also known as VRF; VEGFL

Gene ID: 7423 | Gene type: protein coding

About VEGFB

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,234,584-64,239,264 (from NCBI)

This gene has 4 transcripts (splice variants), 167 orthologues and 4 paralogues. Broad expression in fat (RPKM 106.2), heart (RPKM 26.1) and 23 other tissues.

Summary

This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]

VEGFB Products(2)

mRNA	Protein	Name
NM_001243733.2	NP_001230662.1	vascular endothelial growth factor B isoform VEGFB-167 precursor
NM_003377.5	NP_003368.1	vascular endothelial growth factor B isoform VEGFB-186 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemoattractant activity	IDA IDA: Inferred from direct assay	19275959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11122379	GOA
enables vascular endothelial growth factor receptor 1 binding	IPI IPI: Inferred from physical interaction	12366396	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in induction of positive chemotaxis	IDA IDA: Inferred from direct assay	19275959	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	18259607	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	18259607	GOA
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	18259607	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18259607	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	8637916	GOA
involved in positive regulation of mast cell chemotaxis	IDA IDA: Inferred from direct assay	19275959	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	11122379	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	18259607	GOA
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	18259607	GOA
NOT involved in positive regulation of vascular permeability	IDA IDA: Inferred from direct assay	16109918	GOA
involved in positive regulation of vascular wound healing	IDA IDA: Inferred from direct assay	16109918	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	8637916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VEGFB Protein Structure

PDGF

0
100
207 a.a.

Protein Preferred Names

Protein Names

vascular endothelial growth factor B

VEGF-related factor

Recombinant VEGFB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72431	VEGF-BB Protein, Human (HEK293, Fc)	P49765 (P22-A207)	≥95%

Related Diseases

Diseases

Alias

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Blood Group, Globoside System

Globe Disease	GLOB
Blood Group System, Globoside

Kuhnt-Junius Degeneration

Neovascular Age-Related Macular Degeneration	Exudative Senile Macular Degeneration Of Retina
Senile Macular Degeneration, Wet	Wet Senile Macular Retinal Degeneration
Exudative Age-Related Macular Degeneration	Exudative Macular Degeneration

Macular Retinal Edema

Macular Edema	Macular Oedema
Macular Retinal Oedema	Macular Edema, Cystoid

Retinal Vascular Occlusion

Retinal Vasc. Occlusion	Occlusion Of Retinal Vessels
Retinal Obstruction

Diabetic Macular Edema

Neovascular Glaucoma

Glaucoma, Neovascular	Secondary Angle-Closure Glaucoma With Rubeosis
Glaucoma Neovascular

Endophthalmitis

Central Retinal Vein Occlusion

Crvo

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Degeneration Of Macula And Posterior Pole

Degeneration Of Macula And Posterior Pole Of Retina	Degeneration Of Macula Or Posterior Pole
Macular Degeneration Nos	Degenerative Disorder Of Macula
Drusen Macular Degeneration	Posterior Pole Macular Degeneration Of Eye
Macular Eye Degeneration	Macular Degeneration Of Retina, Unspecified
Pseudohole Degeneration Of Macula Of Retina

Retinal Perforation

Retinal Break	Retinal Perforations
Retinal Dialysis	Retinal Tear
Retinal Break Nos	Ruptured Retina

Cleidocranial Dysplasia

Cleidocranial Dysostosis	CLCD
Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies Only	Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly
CCD	Marie-Sainton Disease
Dysplasia Cleidocranial	Dento-Osseous Dysplasia
Marie-Sainton Syndrome	Dysplasia, Cleidocranial

Retinal Artery Occlusion

Retina Artery Narrowing	Retinal Artery Spasm
Spasm Of Ophthalmic Artery	Retinal Spasm
Vasospasm Of Retina

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Malignant Renovascular Hypertension

Secondary Malignant Renovascular Hypertension

Ureteric Orifice Cancer

Malignant Neoplasm Of Ureteric Orifice Of Urinary Bladder	Malignant Tumor Of Ureteric Orifice
Orifice Of The Ureter

Degenerative Myopia

Pathological Myopia	Myopia, Degenerative
Degenerative Progressive High Myopia	Progressive High Myopia
Progressive High Myopia

Familiar Ovarian Carcinoma

Severe Nonproliferative Diabetic Retinopathy

High Risk Non Proliferative Diabetic Retinopathy

Severe Npdr

Background Diabetic Retinopathy

Non Proliferative Diabetic Retinopathy	Non-Proliferative Diabetic Retinopathy
Nonproliferative Diabetic Retinopathy

Gastroesophageal Junction Adenocarcinoma

Adenocarcinoma Of Cardioesophageal Junction	Adenocarcinoma Of Gastroesophageal Junction
Adenocarcinoma Of The Gastroesophageal Junction

Retinal Vascular Disease

Retinal Vascular	Retinal Vascular Disorder
Retina Circulation Disorder

Vein Disease

Disorder Of Vein

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity	Retrolental Fibroplasia
EVR1	Criswick-Schepens Syndrome
Rop	Exudative Vitreoretinopathy, Familial, Autosomal Dominant
Fevr, Autosomal Dominant	Premature Retinopathy
Vitreoretinopathy, Exudative 1	Autosomal Dominant Familial Exudative Vitreoretinopathy
Fevr	Vitreoretinopathy, Exudative, Type 1
Retinopathy Of Prematurity Nos	Rlf- [Retrolental Fibroplasia]
Rop - [Retinopathy Of Prematurity]	Terry Syndrome

Malignant Secondary Hypertension

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10550	VGB4	Antagonist	/	Unkown
HY-RS15636	VEGFB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990758	Reflocibart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	VEGFB	VGNC	VGNC:78765
Rattus norvegicus	VEGFB	RGD	RGD:619799
Felis catus	VEGFB	VGNC	VGNC:81095
Bos taurus	VEGFB	VGNC	VGNC:97324
Mus musculus	VEGFB	MGD	MGI:106199
Canis familiaris	VEGFB	VGNC	VGNC:48251