CA6 - carbonic anhydrase 6 Gene

Homo sapiens

Also known as CA-VI; GUSTIN

Gene ID: 765 | Gene type: protein coding

About CA6

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:8,945,868-8,975,092 (from NCBI)

This gene has 6 transcripts (splice variants), 228 orthologues and 14 paralogues. Restricted expression toward salivary gland (RPKM 1381.7).

Summary

The protein encoded by this gene is one of several isozymes of Carbonic Anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]

CA6 Products(4)

mRNA	Protein	Name
NM_001215.4	NP_001206.2	carbonic anhydrase 6 isoform 1 precursor
NM_001270500.2	NP_001257429.1	carbonic anhydrase 6 isoform 2 precursor
NM_001270501.2	NP_001257430.1	carbonic anhydrase 6 isoform 3 precursor
NM_001270502.2	NP_001257431.1	carbonic anhydrase 6 isoform 4

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in detection of chemical stimulus involved in sensory perception of bitter taste	IDA IDA: Inferred from direct assay	24248522	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	24248522	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CA6 Protein Structure

Carb_anhydrase

0
100
200
308 a.a.

Protein Preferred Names

Protein Names

carbonic anhydrase 6

carbonate dehydratase VI

Related Diseases

Diseases

Alias

Mammary Analogue Secretory Carcinoma

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Enamel Erosion

Tooth Erosion

Generalized Erosion	Localized Erosion
Generalized Erosions	Erosion, Localized

Multilocular Clear Cell Renal Cell Carcinoma

Cystadenocarcinoma Of Kidney

Renal Cystadenocarcinoma

Aseptic Meningitis

Acute Aseptic Meningitis	Meningitis Aseptic
Meningitis, Aseptic

Parotid Disease

Parotid Diseases

Xerophthalmia

Conjunctival Xerosis

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01773	CA6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CA6	VGNC	VGNC:26656
Mus musculus	CA6	MGD	MGI:1333786
Macaca mulatta	CA6	VGNC	VGNC:70493
Felis catus	CA6	VGNC	VGNC:60277
Canis familiaris	CA6	VGNC	VGNC:38614
Rattus norvegicus	CA6	RGD	RGD:70516
Others	CA6	NCBI

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