2. Gene
  3. CA11 - carbonic anhydrase 11 Gene

CA11 - carbonic anhydrase 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CA-RP; CA-XI; CARP-2; CARPX1; CA-RP II

Gene ID: 770 | Gene type: protein coding

About CA11

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,637,946-48,646,187 (from NCBI)

This gene has 4 transcripts (splice variants), 264 orthologues and 14 paralogues. Biased expression in brain (RPKM 69.9), ovary (RPKM 14.7) and 2 other tissues.

Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has Carbonic Anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]

CA11 Products(1)

mRNA Protein Name
NM_001217.5 NP_001208.2 carbonic anhydrase-related protein 11 precursor

CA11 Protein Structure

Carb_anhydrase

Carb_anhydrase: Eukaryotic-type carbonic anhydrase (63 - 301)

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  • 328 a.a.
Protein Preferred Names Protein Names

carbonic anhydrase-related protein 11

carbonic anhydrase XI

Recombinant CA11 Proteins

Cat. No. Product Name Accession Purity
HY-P7729 Carbonic Anhydrase 11 Protein, Human (HEK293, His) O75493 (V64-R328) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01764 CA11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CA11 VGNC VGNC:60241
Canis familiaris CA11 VGNC VGNC:38606
Rattus norvegicus CA11 RGD RGD:735155
Mus musculus CA11 MGD MGI:1336193
Macaca mulatta CA11 VGNC VGNC:70487
Bos taurus CA11 VGNC VGNC:26649
Others CA11 NCBI