ZNF217 - zinc finger protein 217 Gene

Homo sapiens

Also known as ZABC1

Gene ID: 7764 | Gene type: protein coding

About ZNF217

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:53,567,071-53,597,702 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 14 paralogues. Ubiquitous expression in urinary bladder (RPKM 14.5), spleen (RPKM 14.3) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nuclear speck. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Apr 2022]

ZNF217 Products(2)

mRNA	Protein	Name
NM_001385034.1	NP_001371963.1	zinc finger protein 217 isoform 1
NM_006526.3	NP_006517.1	zinc finger protein 217 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17130829	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17130829	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16940172	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18625718	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16940172	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17130829	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18625718	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	18625718	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	18625718	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF217 Protein Structure

zf-C2H2_4

zf-C2H2

zf-C2H2_4

zf-H2C2_2

0
200
400
600
800
1048 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 217

ZNF217 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82978	ZNF217 Antibody (YA2723)	WB	Human

Related Diseases

Diseases

Alias

Ovarian Serous Cystadenocarcinoma

Serous Cystadenoma	Cystadenoma Serous
Cystadenoma, Serous

Cystadenocarcinoma

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Ovarian Clear Cell Carcinoma

Clear-Cell Ovarian Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16110	ZNF217 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZNF217	VGNC	VGNC:78874
Canis familiaris	ZNF217	VGNC	VGNC:48674
Felis catus	ZNF217	VGNC	VGNC:82318
Rattus norvegicus	ZNF217	RGD	RGD:1308451
Bos taurus	ZNF217	VGNC	VGNC:57037
Mus musculus	ZNF217	MGD	MGI:2685408

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