MAP3K12 - mitogen-activated protein kinase kinase kinase 12 Gene

Homo sapiens

Also known as DLK; MUK; ZPK; ZPKP1; MEKK12; HP09298

Gene ID: 7786 | Gene type: protein coding

About MAP3K12

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,479,669-53,501,539 (from NCBI)

This gene has 11 transcripts (splice variants), 253 orthologues and 23 paralogues. Ubiquitous expression in urinary bladder (RPKM 14.0), brain (RPKM 12.1) and 25 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via Calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

MAP3K12 Products(2)

mRNA	Protein	Name
NM_001193511.2	NP_001180440.1	mitogen-activated protein kinase kinase kinase 12 isoform 1
NM_006301.4	NP_006292.3	mitogen-activated protein kinase kinase kinase 12 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	14697235	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	28111074	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	28111074	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14697235	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K12 Protein Structure

Pkinase_Tyr

0
200
400
600
800
859 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 12

MAPK-upstream kinase

MAP3K12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP3K12	Q12852	EGFR	Homo sapiens	P00533	Ub Reconstruction	20029029

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 34

DEE34	Epileptic Encephalopathy, Early Infantile, 34
Eiee34	Developmental And Epileptic Encephalopathy, 34
Early Infantile Epileptic Encephalopathy 34

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114331	DLK-IN-1	Inhibitor	99.18%	Unkown
HY-RS08049	MAP3K12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAP3K12	VGNC	VGNC:68157
Canis familiaris	MAP3K12	VGNC	VGNC:42968
Macaca mulatta	MAP3K12	VGNC	VGNC:74493
Bos taurus	MAP3K12	VGNC	VGNC:31190
Mus musculus	MAP3K12	MGD	MGI:1346881
Rattus norvegicus	MAP3K12	RGD	RGD:3988
Others	MAP3K12	NCBI

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