SLBP - stem-loop binding protein Gene

Homo sapiens

Also known as HBP

Gene ID: 7884 | Gene type: protein coding

About SLBP

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,692,731-1,712,319 (from NCBI)

This gene has 6 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 30.6), bone marrow (RPKM 27.2) and 25 other tissues.

Summary

This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

SLBP Products(3)

mRNA	Protein	Name
NM_001306074.2	NP_001293003.1	histone RNA hairpin-binding protein isoform 2
NM_001306075.2	NP_001293004.1	histone RNA hairpin-binding protein isoform 3
NM_006527.4	NP_006518.1	histone RNA hairpin-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23286197	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	16912046	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15829567	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cap-dependent translational initiation	IDA IDA: Inferred from direct assay	18025107	GOA
involved in mRNA transport	IDA IDA: Inferred from direct assay	19155325	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15829567	GOA
part of histone mRNA stem-loop binding complex	IPI IPI: Inferred from physical interaction	23286197	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15829567	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLBP Protein Structure

SLBP_RNA_bind

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

histone RNA hairpin-binding protein

hairpin binding protein, histone

SLBP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLBP	Q14493	SLBP	Homo sapiens	Q14493	AFM	23286197
Intra	SLBP	Q14493	SLBP	Homo sapiens	Q14493	GMS	23286197
Intra	SLBP	Q14493	ERI1	Homo sapiens	Q8IV48	GMS	23329046
Intra	SLBP	Q14493	ERI1	Homo sapiens	Q8IV48	X-Ray Diffraction	23329046

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Chromosome 2q31.2 Deletion Syndrome

Blepharochalasis

Dermatolysis Palpebrarum

Adiposa Ptosis

Epiphyseal Dysplasia, Multiple, 2

EDM2	Multiple Epiphyseal Dysplasia 2
Dysplasia, Epiphyseal, Multiple, Type 2

Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12984	SLBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLBP	VGNC	VGNC:46210
Macaca mulatta	SLBP	VGNC	VGNC:77379
Rattus norvegicus	SLBP	RGD	RGD:1584682
Felis catus	SLBP	VGNC	VGNC:65179
Bos taurus	SLBP	VGNC	VGNC:34658
Mus musculus	SLBP	MGD	MGI:108402

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